Evolus Inc., Newport Beach, California.
Dermatol Surg. 2024 Sep 1;50(9S):S42-S47. doi: 10.1097/DSS.0000000000004249. Epub 2024 Jul 1.
Millennials accept and invest in aesthetic procedures more than older generations.
To compare efficacy outcomes between millennial and nonmillennial patients after treatment of glabellar lines with prabotulinumtoxinA.
This was a post hoc analysis of 3 Phase III studies of 20 U prabotulinumtoxinA for the treatment of moderate to severe glabellar lines. Investigator- and/or subject-assessed positive responder rates in the Glabellar Line Scale, Global Aesthetic Improvement Scale, and Subject Satisfaction Scale were compared between millennials (born 1982-2000) and nonmillennials (born ≤1981).
Aesthetic outcomes and subject satisfaction of prabotulinumtoxinA treatment were high in nonmillennials (n = 65) and even higher in millennials (n = 668) at all time points. At Days 7, 14, and 30 post-treatment, positive responder rates were >85% and >97% across all scales in nonmillennials and millennials, respectively, with statistical superiority observed in millennials at multiple time points in virtually all scales. The incidence of treatment-related adverse events was similar between groups.
PrabotulinumtoxinA was highly effective in treating moderate to severe glabellar lines. The greater efficacy seen in millennials may reflect physiological differences related to aging as well as botulinum toxin-mediated effects on mood. The results align well with their aesthetic expectations.
千禧一代比老一代更接受和投资于美容程序。
比较接受保妥适治疗眉间纹的千禧一代和非千禧一代患者的疗效结果。
这是 3 项关于 20U 保妥适治疗中度至重度眉间纹的 III 期研究的事后分析。在眉间线量表、整体美学改善量表和患者满意度量表中，比较了千禧一代（1982-2000 年出生）和非千禧一代（1981 年及以前出生）患者的治疗效果。
非千禧一代（n=65）和千禧一代（n=668）的治疗效果和患者满意度均较高，在所有时间点均>85%和>97%。在治疗后第 7、14 和 30 天，非千禧一代和千禧一代在所有量表中的阳性应答率均>85%，千禧一代在多个时间点在几乎所有量表中均具有统计学优势。两组治疗相关不良事件的发生率相似。
保妥适治疗中度至重度眉间纹效果显著。千禧一代的疗效更好，这可能反映了与衰老相关的生理差异，以及肉毒毒素对情绪的影响。结果与他们的审美期望相符。
