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IL-22Ra2 Levels Remain Elevated in People with Cystic Fibrosis despite Modulator Therapy.

作者信息

Bojanowski Christine M, Lee Stella E, Trevejo-Nunez Giraldina, Bomberger Jennifer M, Schleimer Robert P, Saavedra Milene T, Kolls Jay K

机构信息

Section of Pulmonary Diseases, Critical Care and Environmental Medicine and.

Division of Otolaryngology, Brigham and Women's Hospital, Boston, Massachusetts.

出版信息

Am J Respir Crit Care Med. 2024 Nov 1;210(9):1158-1161. doi: 10.1164/rccm.202402-0458RL.

DOI:10.1164/rccm.202402-0458RL
PMID:39197091
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12042366/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659b/12042366/ca290a198d62/rccm.202402-0458rlf2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659b/12042366/0f814074643f/rccm.202402-0458rlf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659b/12042366/ca290a198d62/rccm.202402-0458rlf2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659b/12042366/0f814074643f/rccm.202402-0458rlf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659b/12042366/ca290a198d62/rccm.202402-0458rlf2.jpg

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本文引用的文献

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Effects of highly effective modulator therapy on the dynamics of the respiratory mucosal environment and inflammatory response in cystic fibrosis.高效调节剂治疗对囊性纤维化呼吸黏膜环境和炎症反应动力学的影响。
Pediatr Pulmonol. 2024 May;59(5):1266-1273. doi: 10.1002/ppul.26898. Epub 2024 Feb 14.
2
Pharmacologic improvement of CFTR function rapidly decreases sputum pathogen density, but lung infections generally persist.药物改善 CFTR 功能可迅速降低痰中病原体密度，但肺部感染通常持续存在。
J Clin Invest. 2023 May 15;133(10):e167957. doi: 10.1172/JCI167957.
3
Impact of elexacaftor-tezacaftor-ivacaftor on bacterial colonization and inflammatory responses in cystic fibrosis.
依洛尤单抗治疗家族性高胆固醇血症的效果和安全性：一项随机对照试验的荟萃分析
Pediatr Pulmonol. 2023 Mar;58(3):825-833. doi: 10.1002/ppul.26261. Epub 2022 Dec 9.
4
Whole-blood transcriptomic responses to lumacaftor/ivacaftor therapy in cystic fibrosis.全血转录组对囊性纤维化中 lumacaftor/ivacaftor 治疗的反应。
J Cyst Fibros. 2020 Mar;19(2):245-254. doi: 10.1016/j.jcf.2019.08.021. Epub 2019 Aug 29.
5
Clinical predictors of cystic fibrosis chronic rhinosinusitis severity.囊性纤维化慢性鼻-鼻窦炎严重程度的临床预测因素。
Int Forum Allergy Rhinol. 2019 Jul;9(7):759-765. doi: 10.1002/alr.22332. Epub 2019 Jun 4.
6
Inactivation of the interleukin-22 pathway in the airways of cystic fibrosis patients.气道中白细胞介素-22 通路在囊性纤维化患者中的失活。
Cytokine. 2019 Jan;113:470-474. doi: 10.1016/j.cyto.2018.10.015. Epub 2018 Oct 28.
7
Antiinflammatory effects of bromodomain and extraterminal domain inhibition in cystic fibrosis lung inflammation.溴结构域和额外末端结构域抑制在囊性纤维化肺部炎症中的抗炎作用
JCI Insight. 2016 Jul 21;1(11). doi: 10.1172/jci.insight.87168.
8
Interleukin-22 regulates antimicrobial peptide expression and keratinocyte differentiation to control Staphylococcus aureus colonization of the nasal mucosa.白细胞介素-22 调控抗菌肽表达和角质形成细胞分化，以控制金黄色葡萄球菌定植于鼻腔黏膜。
Mucosal Immunol. 2016 Nov;9(6):1429-1441. doi: 10.1038/mi.2016.24. Epub 2016 Mar 23.
9
Patients with cystic fibrosis have inducible IL-17+IL-22+ memory cells in lung draining lymph nodes.囊性纤维化患者的肺引流淋巴结中存在诱导型 IL-17+IL-22+记忆细胞。
J Allergy Clin Immunol. 2013 Apr;131(4):1117-29, 1129.e1-5. doi: 10.1016/j.jaci.2012.05.036. Epub 2012 Jul 11.
10
Interleukin-17A induces bicarbonate secretion in normal human bronchial epithelial cells.白细胞介素-17A可诱导正常人支气管上皮细胞分泌碳酸氢盐。
Am J Physiol Lung Cell Mol Physiol. 2009 Feb;296(2):L257-66. doi: 10.1152/ajplung.00344.2007. Epub 2008 Dec 12.