Centre for Materials Science and School of Chemistry and Physics, Queensland University of Technology, Brisbane, QLD 4000, Australia.
Department of Chemistry; Department of Chemical and Biochemical Engineering, The University of Western Ontario, London, Ontario N6A 5B7, Canada.
Biomacromolecules. 2024 Sep 9;25(9):5417-5436. doi: 10.1021/acs.biomac.4c00690. Epub 2024 Aug 28.
There has been growing interest in polymeric systems that break down or undergo property changes in response to stimuli. Such polymers can play important roles in biological systems, where they can be used to control the release of therapeutics, modulate imaging signals, actuate movement, or direct the growth of cells. In this Perspective, after discussing the most important stimuli relevant to biological applications, we will present a selection of recent exciting developments. The growing importance of stimuli-responsive polysaccharides will be discussed, followed by a variety of stimuli-responsive polymeric systems for the delivery of small molecule drugs and nucleic acids. Switchable polymers for the emerging area of therapeutic response measurement in theranostics will be described. Then, the diverse functions that can be achieved using hydrogels cross-linked covalently, as well as by various dynamic approaches will be presented. Finally, we will discuss some of the challenges and future perspectives for the field.
人们对能够响应刺激而发生降解或物性变化的聚合体系越来越感兴趣。这类聚合物在生物系统中可发挥重要作用，例如用于控制药物释放、调节成像信号、驱动运动或引导细胞生长。在本文中，我们在讨论了与生物应用相关的最重要的刺激因素后，将介绍一些近期令人兴奋的进展。我们将讨论刺激响应型多糖日益重要的作用，然后介绍各种用于小分子药物和核酸传递的刺激响应型聚合物体系。我们将介绍用于治疗反应测量这一新兴治疗学领域的可切换聚合物。接下来，我们将介绍通过共价交联和各种动态方法来实现的不同功能。最后，我们将讨论该领域的一些挑战和未来展望。
