Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Carbohydr Polym. 2021 Feb 15;254:117422. doi: 10.1016/j.carbpol.2020.117422. Epub 2020 Nov 22.
Chemotherapy as the main cancer treatment method has non-specific effects and various side-effects. Accordingly, significant attempts have been conducted to enhance its efficacy through design and development of "smart" drug delivery systems (DDSs). In this context, natural gums, as a nice gift by the nature, can be exploited as stimuli-responsive DDSs for cancer treatment in part due to their renewability, availability, low cost, bioactivity, biocompatibility, low immunogenicity, biodegradability, and acceptable stability in both in vitro and in vivo conditions. However, some shortcomings (e.g., poor mechanical properties and high hydration rate) restrict their biomedical application ranges that can be circumvented through modification process (e.g., grafting of stimuli-responsive polymers or small molecules) to obtain tailored biomaterials. This review article aimed to compile the stimuli-responsive DDSs based on natural gums. In addition, different types of stimuli, the fundamental features of natural gums, as well as their chemical modification approaches are also shortly highlighted.
化疗作为癌症的主要治疗方法，具有非特异性作用和多种副作用。因此，人们一直在努力通过设计和开发“智能”药物输送系统（DDS）来提高其疗效。在这种情况下，天然胶作为大自然的一份美好礼物，可以被开发为用于癌症治疗的响应型 DDS，部分原因是它们具有可再生性、可用性、低成本、生物活性、生物相容性、低免疫原性、可生物降解性以及在体外和体内条件下都具有可接受的稳定性。然而，一些缺点（例如，机械性能差和高水合速率）限制了它们在生物医学中的应用范围，可以通过修饰过程（例如，接枝响应型聚合物或小分子）来克服这些缺点，以获得定制的生物材料。本文旨在综述基于天然胶的响应型 DDS。此外，还简要介绍了不同类型的刺激物、天然胶的基本特性以及它们的化学修饰方法。
