Margolis R N
Biochem Biophys Res Commun. 1985 Feb 15;126(3):1215-21. doi: 10.1016/0006-291x(85)90315-8.
Glycogen synthase first appears in significant levels in fetal rat liver on day 18 of gestation (22 day term), but in a mostly inactive, phospho- form. This was reflected in a decreased affinity for its allosteric activator (increased A0.5 for glucose-6-phosphate), and with limited glycogen synthesis and accumulation. Peak glycogen synthesis occurs on day 21 of gestation, and glycogen synthase is in a more dephospho-form with decreased A0.5 for G6P and increased -G6P/+G6P activity ratio. The data suggest that a significant change in phosphorylation state of synthase occurs in late gestation to facilitate the large increase in glycogen synthesis and accumulation.
糖原合酶在妊娠第18天（足月为22天）时首次在胎鼠肝脏中大量出现，但大多处于无活性的磷酸化形式。这表现为对其变构激活剂的亲和力降低（葡萄糖-6-磷酸的A0.5增加），糖原合成和积累有限。糖原合成在妊娠第21天达到峰值，此时糖原合酶处于更多的去磷酸化形式，G6P的A0.5降低，-G6P/+G6P活性比值增加。数据表明，在妊娠后期合酶的磷酸化状态发生了显著变化，以促进糖原合成和积累的大幅增加。
