Bourbon J, Gilbert M
Biol Neonate. 1981;40(1-2):38-45. doi: 10.1159/000241470.
In the near-term rat fetus liver, insulin decreased phosphorylase a activity, slightly increased synthase a activity and increased both glycogen content and 14C-glucose incorporation into glycogen; anti-insulin serum increased phosphorylase a activity and decreased glucose incorporation but did not modify synthase a activity. When pregnant rats were previously rendered hypoglycemia, insulin injection to the fetus enhanced glycogen accumulation. It is concluded that insulin is a regulatory factor of secondary importance for liver glycogen storage through its action on phosphorylase activity.
在近期的大鼠胎儿肝脏中，胰岛素降低了磷酸化酶a的活性，略微增加了合酶a的活性，并增加了糖原含量以及14C-葡萄糖掺入糖原的量；抗胰岛素血清增加了磷酸化酶a的活性并降低了葡萄糖掺入量，但未改变合酶a的活性。当怀孕大鼠先前出现低血糖时，向胎儿注射胰岛素可增强糖原积累。结论是，胰岛素通过对磷酸化酶活性的作用，是肝脏糖原储存的次要调节因子。
