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揭示既往抑郁和与创伤相关的认知过程对创伤后抑郁的影响:一项对烧伤幸存者进行的为期 2 年的前瞻性研究。

Unravelling the impact of prior depression and trauma-related cognitive processes on depression following trauma: A 2-year prospective study of burn survivors.

机构信息

Graduate Institute of Behavioral Sciences, Chang Gung University, Taoyuan, Taiwan; Department of Psychiatry, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Section of Department of Child and Adolescent Psychiatry, Department of Psychiatry, Chang Gung Memorial Hospital at Taoyuan, Taoyuan, Taiwan; Chang Gung University College of Medicine, Taoyuan, Taiwan.

出版信息

Gen Hosp Psychiatry. 2024 Sep-Oct;90:157-164. doi: 10.1016/j.genhosppsych.2024.08.012. Epub 2024 Aug 22.

Abstract

OBJECTIVE

Individuals with severe burn injuries may develop depression, yet knowledge about psychological risk factors for depression following trauma is limited. This study investigated the prospective impact and interplay of prior depression and trauma-related cognitive processes (posttraumatic negative appraisals and trauma-related rumination) to depressive symptoms between 6 and 24 months after burn injury.

METHOD

Taiwanese adult survivors of burn (N = 118) participated in surveys immediately post-burn and at 6-, 12-, and 24-months follow-up. Participants were 7 5% men, with an average age of 41.8 years and an average of TBSA of 18.3%.

RESULTS

A total of 8.5%, 5.9%, and 4.2% met criteria for probable major depression at 6, 12, and 24 months post-burn, respectively. The prevalence increased to 23.7%, 11.0%, and 5.9% using the cutoff on the PHQ-9. Prior depression and trauma-related cognitive processes immediately post-burn explained 13.5%, 20.5%, and 18.6% of the variance in depressive symptoms at 6, 12, and 24 months post-burn, respectively. Posttraumatic negative appraisals strongly predicted depressive symptoms post-burn across follow-ups. Moreover, posttraumatic negative appraisals significantly mediated the effect of prior depression on subsequent depressive symptoms across follow-ups. Prior depression significantly moderated the effect of trauma-related rumination on depressive symptoms at 6 months post-burn.

CONCLUSIONS

Our results are the first to demonstrate the role and interplay of prior depression and trauma-related cognitive processes in post-burn depression. Findings highlight that pre-and post-trauma psychological factors jointly affect depression following trauma, broadening the applicability of cognitive theories of PTSD.

摘要

目的

严重烧伤患者可能会出现抑郁,但关于创伤后抑郁的心理风险因素知之甚少。本研究调查了先前抑郁和与创伤相关的认知过程(创伤后负面评价和与创伤相关的反刍)对烧伤后 6 至 24 个月期间抑郁症状的前瞻性影响和相互作用。

方法

台湾烧伤成年幸存者(N=118)在烧伤后立即以及 6、12 和 24 个月随访时参加了调查。参与者中 75%为男性,平均年龄为 41.8 岁,烧伤面积平均为 18.3%。

结果

分别有 8.5%、5.9%和 4.2%的人在烧伤后 6、12 和 24 个月时符合可能的重度抑郁症标准。使用 PHQ-9 的截定点,患病率分别增加到 23.7%、11.0%和 5.9%。烧伤后立即的先前抑郁和与创伤相关的认知过程分别解释了 6、12 和 24 个月后抑郁症状的 13.5%、20.5%和 18.6%。创伤后负面评价强烈预测了烧伤后的抑郁症状。此外,创伤后负面评价在整个随访过程中显著中介了先前抑郁对随后抑郁症状的影响。先前的抑郁显著调节了与创伤相关的反刍对烧伤后 6 个月时抑郁症状的影响。

结论

我们的研究结果首次证明了先前抑郁和与创伤相关的认知过程在烧伤后抑郁中的作用和相互作用。研究结果强调了创伤前后心理因素共同影响创伤后抑郁,拓宽了 PTSD 认知理论的适用性。

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