Department of Bioinformatics and Biochemistry, Braunschweig Integrated Centre of Systems Biology (BRICS), Technische Universität Braunschweig, Braunschweig, Germany; Research Group Cellular Metabolism in Infection, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Department of Bioinformatics and Biochemistry, Braunschweig Integrated Centre of Systems Biology (BRICS), Technische Universität Braunschweig, Braunschweig, Germany; Research Group Cellular Metabolism in Infection, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Curr Opin Biotechnol. 2024 Oct;89:103183. doi: 10.1016/j.copbio.2024.103183. Epub 2024 Aug 27.
The impact of bacteria and viruses on tumor growth has long been recognized. In recent decades, interest in the role of microorganisms in the tumor microenvironment (TME) has expanded. Infections induce metabolic reprogramming and influence immune responses within the TME that may either support proliferation and metastasis or limit tumor growth. The natural ability to infect cells and alter the TME is also utilized for cancer detection and treatment. In this review, we discuss recent discoveries about the mechanisms of bacteria and viruses affecting TME, as well as strategies in cancer therapy focusing on metabolic alterations. Infections with engineered bacteria and viruses represent promising therapeutic approaches to develop novel and more effective therapies to constrain tumor growth.
细菌和病毒对肿瘤生长的影响早已被认识到。近几十年来，人们对微生物在肿瘤微环境（TME）中的作用的兴趣不断扩大。感染会诱导 TME 中的代谢重编程并影响免疫反应，这些反应可能支持增殖和转移，也可能限制肿瘤生长。细胞感染和改变 TME 的天然能力也被用于癌症的检测和治疗。在这篇综述中，我们讨论了关于细菌和病毒影响 TME 的机制的最新发现，以及专注于代谢改变的癌症治疗策略。工程化细菌和病毒的感染代表了开发新型、更有效的限制肿瘤生长疗法的有前途的治疗方法。
