Taghzouti K, Simon H, Tazi A, Dantzer R, Le Moal M
Behav Brain Res. 1985 Jan;15(1):1-8. doi: 10.1016/0166-4328(85)90012-9.
In this study the relationship between 6-hydroxydopamine lesions of dopaminergic innervation of the lateral septum and schedule-induced polydipsia was examined. Animals with lesions were found to have a significant increase in water intake during a test involving an intermittent schedule of food delivery. Additional experiments with these animals showed that lesions had no effect on: (i) spontaneous drinking, the amount of drinking after 24 h food or water deprivation, water intake following a hypertonic saline challenge; (ii) eating behavior with or without food deprivation; and (iii) spontaneous locomotor activity. This increase in adjunctive behavior is discussed in the light of an enhanced frustrative effect induced by the septal lesions.
在本研究中，研究了外侧隔区多巴胺能神经支配的6-羟基多巴胺损伤与程序性诱导的饮多症之间的关系。发现有损伤的动物在涉及间歇性食物递送的测试期间饮水量显著增加。对这些动物进行的额外实验表明，损伤对以下方面没有影响：（i）自发饮水、禁食或禁水24小时后的饮水量、高渗盐水刺激后的饮水量；（ii）有无食物剥夺情况下的进食行为；以及（iii）自发运动活动。根据隔区损伤引起的增强的挫折效应讨论了这种辅助行为的增加。
