抽动秽语综合征的对照研究。VII. 总结：一种导致边缘系统去抑制的常见遗传性疾病。
A controlled study of Tourette syndrome. VII. Summary: a common genetic disorder causing disinhibition of the limbic system.
作者信息
Comings D E
机构信息
Department of Medical Genetics, City of Hope National Medical Center, Duarte, CA 91010.
出版信息
Am J Hum Genet. 1987 Nov;41(5):839-66.
Abstract
Tourette syndrome (TS) is one of the most common genetic disorders affecting man. Approximately one in 100 individuals manifests one or more of the aspects of the TS gene. This series of papers has emphasized that although motor and vocal tics are the hallmark of TS, the complete range of behavioral problems is much broader. This spectrum of behavior can be explained on the basis of the TS gene causing an imbalance of the mesencephalic-mesolimbic dopamine pathways, resulting in disinhibition of the limbic system.
摘要
抽动秽语综合征（TS）是影响人类的最常见的遗传性疾病之一。大约每100人中就有1人表现出TS基因的一个或多个方面。这一系列论文强调，尽管运动和发声抽动是TS的标志，但行为问题的完整范围要广泛得多。这种行为谱可以基于TS基因导致中脑-边缘多巴胺通路失衡，从而导致边缘系统去抑制来解释。
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