Goodman N W, Black A M
Br J Anaesth. 1985 Mar;57(3):319-25. doi: 10.1093/bja/57.3.319.
Baseline control estimations of the ventilatory response to carbon dioxide by the rebreathing method were attempted in 92 patients. When analysed retrospectively, only 53 were both technically and statistically satisfactory, although even these gave rise to some doubts. As the breath-by-breath correlation between ventilation (VI) and end-tidal carbon dioxide (PE'CO2) decreased there was a tendency for the gradients to become suspiciously low and for estimates in an individual gradient to become sensitive to the method of analysis. Even so, when responses were grouped according to correlation, the method of analysis did not alter the mean gradient within a group. Single estimates of the carbon dioxide response at each stage of a study may not be a very powerful technique in clinical research; multiple estimates, if they can be arranged, would be more satisfactory.
我们尝试采用重复呼吸法对92例患者进行二氧化碳通气反应的基线对照评估。回顾性分析时发现，尽管这其中仅有53例在技术和统计学上均令人满意，但即便如此仍存在一些疑问。随着通气量（VI）与呼气末二氧化碳（PE'CO2）逐次呼吸之间的相关性降低，梯度有变得异常低的趋势，且个体梯度的评估对分析方法变得敏感。即便如此，当根据相关性对反应进行分组时，分析方法并未改变组内的平均梯度。在临床研究中，对研究每个阶段的二氧化碳反应进行单次评估可能并非非常有效的技术；如果能够进行多次评估，将会更令人满意。
