米索前列醇（一种口服活性合成E1类似物前列腺素）对食物刺激的胃酸分泌的抑制作用。
Inhibition of food stimulated acid secretion by misoprostol, an orally active synthetic E1 analogue prostaglandin.
作者信息
Ramage J K, Denton A, Williams J G
出版信息
Br J Clin Pharmacol. 1985 Jan;19(1):9-12. doi: 10.1111/j.1365-2125.1985.tb02606.x.
Abstract
The effect of 200 micrograms misoprostol (a synthetic prostaglandin E1 analogue) on food stimulated intragastric acidity has been monitored over a 9 h period in 16 normal volunteers. Misoprostol caused a significant inhibition of intragastric acidity for 2 h post-dosing, but no significant effect was seen thereafter on either basal or food stimulated acidity.
摘要
在16名正常志愿者中，对200微克米索前列醇（一种合成的前列腺素E1类似物）对食物刺激引起的胃内酸度的影响进行了9小时的监测。米索前列醇在给药后2小时对胃内酸度有显著抑制作用，但此后对基础酸度或食物刺激引起的酸度均无显著影响。
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