米索前列醇（一种口服活性合成E1类似物前列腺素）对食物刺激的胃酸分泌的抑制作用。
Inhibition of food stimulated acid secretion by misoprostol, an orally active synthetic E1 analogue prostaglandin.
作者信息
Ramage J K, Denton A, Williams J G
出版信息
Br J Clin Pharmacol. 1985 Jan;19(1):9-12. doi: 10.1111/j.1365-2125.1985.tb02606.x.
Abstract
The effect of 200 micrograms misoprostol (a synthetic prostaglandin E1 analogue) on food stimulated intragastric acidity has been monitored over a 9 h period in 16 normal volunteers. Misoprostol caused a significant inhibition of intragastric acidity for 2 h post-dosing, but no significant effect was seen thereafter on either basal or food stimulated acidity.
摘要
在16名正常志愿者中，对200微克米索前列醇（一种合成的前列腺素E1类似物）对食物刺激引起的胃内酸度的影响进行了9小时的监测。米索前列醇在给药后2小时对胃内酸度有显著抑制作用，但此后对基础酸度或食物刺激引起的酸度均无显著影响。
相似文献
1
Inhibition of food stimulated acid secretion by misoprostol, an orally active synthetic E1 analogue prostaglandin.
Br J Clin Pharmacol. 1985 Jan;19(1):9-12. doi: 10.1111/j.1365-2125.1985.tb02606.x.
2
Inhibition of nocturnal gastric secretion in normal human volunteers by misoprostol: a synthetic prostaglandin E1 methyl ester analog.
Am J Gastroenterol. 1982 Dec;77(12):902-4.
3
[Intragastric acidity under the prostaglandin E2 analog trimoprostil. Increased inhibitory effect through administration after meals].
Arzneimittelforschung. 1986 Mar;36(3):500-2.
4
Prostaglandin E analogue inhibition of intrinsic factor release.
Scand J Gastroenterol. 1988 Aug;23(6):650-4. doi: 10.3109/00365528809093926.
5
Dose response inhibition in man of meal-stimulated gastric acid secretion by 15(R)-15-methyl prostaglandin E2, given orally.
Gut. 1981 Sep;22(9):728-31. doi: 10.1136/gut.22.9.728.
6
A new prostaglandin E1 analogue (CL-115,574) II. Effects on gastric acid secretion in the dog.
Prostaglandins. 1981 Dec;22(6):971-8. doi: 10.1016/0090-6980(81)90025-3.
7
Oral prostaglandin E analogues induce intestinal migrating motor complexes after a meal in dogs. Evidence for a central mechanism.
Gastroenterology. 1990 Apr;98(4):888-93. doi: 10.1016/0016-5085(90)90012-p.
8
Effect of enprostil, a synthetic prostaglandin E2 on 24 hour intragastric acidity, nocturnal acid and pepsin secretion.
Gut. 1986 Sep;27(9):1054-7. doi: 10.1136/gut.27.9.1054.
9
Gastric acid secretion in the toad Bufo marinus with the description of a new technique for in vivo monitoring.
Comp Biochem Physiol A Comp Physiol. 1985;81(2):325-7. doi: 10.1016/0300-9629(85)90142-2.
10
[Effect of 16,16-dimethyl-PG E2 on the 24 hours intragastric acidity in man].
Z Gastroenterol. 1982 Oct;20(10):613-6.
引用本文的文献
1
Helicobacter pylori infection, ABO blood group, and effect of misoprostol on gastroduodenal mucosa in NSAID-treated patients with rheumatoid arthritis.
Dig Dis Sci. 1993 Sep;38(9):1688-96. doi: 10.1007/BF01303179.
2
Interim results of a multicenter international comparison of misoprostol and cimetidine in the treatment of out-patients with benign gastric ulcers.
Dig Dis Sci. 1985 Nov;30(11 Suppl):178S-184S. doi: 10.1007/BF01309406.
3
Misoprostol clinical pharmacology. Establishment of activity in man.
Dig Dis Sci. 1985 Nov;30(11 Suppl):136S-141S. doi: 10.1007/BF01309400.
4
Misoprostol. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of peptic ulcer disease.
Drugs. 1987 Jan;33(1):1-30. doi: 10.2165/00003495-198733010-00001.
本文引用的文献
1
Inhibition of food stimulated acid secretion by fenoctimine, a new anti-secretory agent.
Br J Clin Pharmacol. 1983 Jun;15(6):673-6. doi: 10.1111/j.1365-2125.1983.tb01548.x.
2
Inhibition of nocturnal gastric secretion in normal human volunteers by misoprostol: a synthetic prostaglandin E1 methyl ester analog.
Am J Gastroenterol. 1982 Dec;77(12):902-4.
3
SC-29333: a potent inhibitor of canin gastric secretion.
Am J Dig Dis. 1976 Dec;21(12):1049-57. doi: 10.1007/BF01071862.
4
Effects of a prostaglandin E1 derivative, SC-29333, and aspirin on gastric ionic fluxes and potential difference in dogs.
J Pharmacol Exp Ther. 1979 Aug;210(2):283-8.
5
pH or hydrogen-ion concentration in statistics?
Lancet. 1977 Oct 15;2(8042):826. doi: 10.1016/s0140-6736(77)90763-2.
6
24-hour control of intragastric acidity by cimetidine in duodenal-ulcer patients.
Lancet. 1975 Nov 29;2(7944):1069-72. doi: 10.1016/s0140-6736(75)90434-1.
7
Effect of cimetidine on 24-hour intragastric acidity in normal subjects.
Gut. 1976 Feb;17(2):133-8. doi: 10.1136/gut.17.2.133.
Zotero 插件