Gossypol, a potent inhibitor of arachidonate 5- and 12-lipoxygenases.
作者信息
Hamasaki Y, Tai H H
出版信息
Biochim Biophys Acta. 1985 Mar 27;834(1):37-41. doi: 10.1016/0005-2760(85)90173-0.
PMID:3919771
Abstract
Gossypol inhibited 5- and 12-lipoxygenases of rat basophilic leukemia (RBL-1) cells with ID50 of 0.3 microM and 0.7 microM, respectively. Nearly two orders of magnitude of higher concentration of gossypol was required to inhibit prostaglandin synthetase. The inhibition was of a non-competitive type with respect to arachidonate.
摘要
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