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多巴胺能系统和神经元:在多种神经疾病中的作用。

Dopaminergic system and neurons: Role in multiple neurological diseases.

机构信息

Beijing University of Chinese Medicine, Beijing, 102488, China.

Beijing Normal University, Beijing, 100875, China.

出版信息

Neuropharmacology. 2024 Dec 1;260:110133. doi: 10.1016/j.neuropharm.2024.110133. Epub 2024 Aug 27.

Abstract

The dopaminergic system is a complex and powerful neurotransmitter system in the brain. It plays an important regulatory role in motivation, reward, cognition, and motor control. In recent decades, research in the field of the dopaminergic system and neurons has increased exponentially and is gradually becoming a point of intervention in the study and understanding of a wide range of neurological diseases related to human health. Studies have shown that the dopaminergic system and neurons are involved in the development of many neurological diseases (including, but not limited to Parkinson's disease, schizophrenia, depression, attention deficit hyperactivity disorder, etc.) and that dopaminergic neurons either have too much stress or too weak function in the dopaminergic system can lead to disease. Therefore, targeting dopaminergic neurons is considered key to treating these diseases. This article provides a comprehensive review of the dopaminergic system and neurons in terms of brain region distribution, physiological function and subtypes of dopaminergic neurons, as well as the role of the dopaminergic system and neurons in a variety of diseases.

摘要

多巴胺能系统是大脑中一种复杂而强大的神经递质系统。它在动机、奖励、认知和运动控制方面发挥着重要的调节作用。近几十年来,多巴胺能系统和神经元领域的研究呈指数级增长,逐渐成为研究和理解与人类健康相关的多种神经疾病的切入点。研究表明,多巴胺能系统和神经元参与了许多神经疾病(包括但不限于帕金森病、精神分裂症、抑郁症、注意缺陷多动障碍等)的发生,多巴胺能系统中的多巴胺能神经元要么压力过大,要么功能过弱,都会导致疾病。因此,针对多巴胺能神经元被认为是治疗这些疾病的关键。本文从脑区分布、多巴胺能神经元的生理功能和亚型,以及多巴胺能系统和神经元在多种疾病中的作用等方面,对多巴胺能系统和神经元进行了全面的综述。

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