Department of Public Health and Environmental Medicine, The Jikei University School of Medicine.
Environ Health Prev Med. 2024;29:44. doi: 10.1265/ehpm.24-00158.
This study examined the association between neurological symptoms and quality of life (QoL) in patients with neurofibromatosis type 2 (NF2) using a national database of all patients who newly claimed for medical expense subsidies in Japan from 2015 to 2019.
The Japanese Ministry of Health, Labour and Welfare provided access to the "National Database of Designated Intractable Diseases of Japan" containing the "Medical Certificates of Designated Intractable Diseases" of all patients with NF2. The database included information on five items of QoL: "mobility," "self-care," "usual activities," "pain/discomfort," and "anxiety/depression." To examine the association between the presence/absence of neurological symptoms and QoL, multivariable logistic regression analyses were performed, adjusted for potential confounders.
Data from 187 patients (97 females and 90 males; mean (standard deviation) age, 43.1 (17.9) years) were analyzed. Overall, 31% to 55% of patients were recorded as having moderate/severe impairment of QoL. Spinal dysfunction was significantly associated with deterioration of all components of QoL, whereas speech dysfunction and hemiparesis were specifically associated with physical health-related components of QoL. Spinal dysfunction, facial nerve palsy, and age 25-64 years were significantly associated with "anxiety/depression."
In the present epidemiological study using a national database of NF2 in Japan, spinal dysfunction was significantly associated with deterioration of all components of QoL, including subjective and mental health-related components of QoL, whereas speech dysfunction and hemiparesis were specifically associated with physical health-related components of QoL.
本研究使用日本从 2015 年至 2019 年所有新申请医疗费用补贴的患者的国家数据库，调查了神经纤维瘤病 2 型（NF2）患者的神经症状与生活质量（QoL）之间的关系。
日本厚生劳动省提供了访问权限，以获取包含所有 NF2 患者的“日本指定难治性疾病国家数据库”中的“指定难治性疾病医疗证明”。该数据库包含五个 QoL 项目的信息：“移动性”、“自理”、“日常活动”、“疼痛/不适”和“焦虑/抑郁”。为了检验是否存在神经症状与 QoL 之间的关联，进行了多变量逻辑回归分析，并对潜在混杂因素进行了调整。
对 187 名患者（97 名女性和 90 名男性；平均（标准差）年龄为 43.1（17.9）岁）的数据进行了分析。总体而言，31%至 55%的患者记录为存在中度/重度 QoL 受损。脊柱功能障碍与所有 QoL 成分的恶化显著相关，而言语功能障碍和偏瘫与身体健康相关的 QoL 成分具体相关。脊柱功能障碍、面神经瘫痪和 25-64 岁年龄与“焦虑/抑郁”显著相关。
在本研究中，使用日本 NF2 的国家数据库进行了一项流行病学研究，结果表明脊柱功能障碍与所有 QoL 成分的恶化显著相关，包括主观和心理健康相关的 QoL 成分，而言语功能障碍和偏瘫与身体健康相关的 QoL 成分具体相关。
