Department of Epidemiology and Health Statistics, School of Public Health, University of South China, Hengyang 421001, Hunan, China;Department of Maternal and Child Health, Xiangya School of Public Health, Central South University, Changsha 410008, Hunan, China.
Department of Maternal and Child Health, Xiangya School of Public Health, Central South University, Changsha 410008, Hunan, China.
Biomed Environ Sci. 2024 Jul 20;37(7):762-773. doi: 10.3967/bes2024.079.
To systematically summarize the published literature on the genetic variants associated with nonalcoholic fatty liver disease (NAFLD).
Literature from Web of Science, PubMed, and Embase between January 1980 and September 2022 was systematically searched. Meta-analyses of the genetic variants were conducted using at least five data sources. The epidemiologic credibility of the significant associations was graded using the Venice criteria.
Based on literature screening, 399 eligible studies were included, comprising 381 candidate gene association, 16 genome-wide association, and 2 whole-exome sequencing studies. We identified 465 genetic variants in 173 genes in candidate gene association studies, and 25 genetic variants in 17 genes were included in the meta-analysis. The meta-analysis identified 11 variants in 10 genes that were significantly associated with NAFLD, with cumulative epidemiological evidence of an association graded as strong for two variants in two genes ( ), moderate for four variants in three genes ( and ), and weak for five variants in five genes ( and ).
This study identified six variants in five genes that had moderate to strong evidence of an association with NAFLD, which may help understand the genetic architecture of NAFLD risk.
系统总结与非酒精性脂肪性肝病（NAFLD）相关的遗传变异的已发表文献。
系统检索了 1980 年 1 月至 2022 年 9 月间 Web of Science、PubMed 和 Embase 上的文献。使用至少五个数据源对遗传变异进行了荟萃分析。使用威尼斯标准对显著关联的流行病学可信度进行分级。
根据文献筛选，共纳入 399 项符合条件的研究，包括 381 项候选基因关联研究、16 项全基因组关联研究和 2 项全外显子组测序研究。我们在候选基因关联研究中确定了 173 个基因中的 465 个遗传变异，在荟萃分析中纳入了 17 个基因中的 25 个遗传变异。荟萃分析确定了 10 个基因中的 11 个变异与 NAFLD 显著相关，两个基因中的两个变异（ ）的关联具有较强的累积流行病学证据，三个基因中的四个变异（ ）和五个基因中的五个变异（ ）的关联具有中等强度的累积流行病学证据。
本研究确定了五个基因中的六个变异与 NAFLD 具有中度至强的关联证据，这可能有助于理解 NAFLD 风险的遗传结构。
