月经周期中外周血自然杀伤细胞活性的变化。
Variation in natural killer activity in peripheral blood during the menstrual cycle.
作者信息
Sulke A N, Jones D B, Wood P J
出版信息
Br Med J (Clin Res Ed). 1985 Mar 23;290(6472):884-6. doi: 10.1136/bmj.290.6472.884.
Abstract
Natural killer activity was measured sequentially in normal female volunteers through their menstrual cycle. During the periovulatory period there was a significant fall in natural killer activity compared with in normal male volunteers. This variation was not apparent in women taking oral contraception. Cytotoxic activity was not related to oestradiol concentrations in individual women. The data support an interaction between immunological activity and sex hormones over the normal physiological range and would account for the described reduction in natural killer activity in pooled blood from female blood donors.
摘要
在正常女性志愿者的整个月经周期中，对其自然杀伤活性进行了连续测量。与正常男性志愿者相比，在排卵期前后，自然杀伤活性显著下降。这种变化在服用口服避孕药的女性中并不明显。细胞毒性活性与个体女性的雌二醇浓度无关。这些数据支持了免疫活性和性激素在正常生理范围内的相互作用，并且可以解释女性献血者混合血液中自然杀伤活性下降的现象。
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