Klick Labs, Klick Inc., Toronto, ON, Canada.
Faculty of Science, University of Ontario Institute of Technology, Oshawa, ON, Canada.
Sci Rep. 2024 Aug 28;14(1):19012. doi: 10.1038/s41598-024-69620-z.
Glucose levels in the body have been hypothesized to affect voice characteristics. One of the primary justifications for voice changes are due to Hooke's law, in which a variation in the tension, mass, or length of the vocal folds, mediated by the body's glucose levels, results in an alteration in their vibrational frequency. To explore this hypothesis, 505 participants were fitted with a continuous glucose monitor (CGM) and instructed to record their voice using a custom mobile application up to six times daily for 2 weeks. Glucose values from CGM were paired to voice recordings to create a sampled dataset that closely resembled the glucose profile of the comprehensive CGM dataset. Glucose levels and fundamental frequency (F0) had a significant positive association within an individual, and a 1 mg/dL increase in CGM recorded glucose corresponded to a 0.02 Hz increase in F0 (CI 0.01-0.03 Hz, P < 0.001). This effect was also observed when the participants were split into non-diabetic, prediabetic, and Type 2 Diabetic classifications (P = 0.03, P = 0.01, & P = 0.01 respectively). Vocal F0 increased with blood glucose levels, but future predictive models of glucose levels based on voice may need to be personalized due to high intraclass correlation.
人们推测，体内的葡萄糖水平会影响声音特征。声音发生变化的主要原因之一是胡克定律，即通过身体的葡萄糖水平，声带张力、质量或长度的变化会导致其振动频率发生变化。为了验证这一假说，研究人员为 505 名参与者配备了连续血糖监测仪（CGM），并指导他们使用定制的移动应用程序每天最多录制六次声音，持续两周。将 CGM 的血糖值与语音录音配对，创建一个采样数据集，该数据集非常接近全面 CGM 数据集的血糖曲线。在个体内部，血糖水平和基频（F0）之间存在显著的正相关关系，CGM 记录的血糖值每增加 1mg/dL，F0 就会增加 0.02Hz（CI 0.01-0.03Hz，P<0.001）。当参与者被分为非糖尿病、糖尿病前期和 2 型糖尿病分类时，也观察到了这种效果（P=0.03、P=0.01 和 P=0.01 分别）。F0 随着血糖水平的升高而升高，但基于声音的血糖水平的未来预测模型可能需要个性化，因为个体内相关性很高。
