Aminuddin Amilia, Noor Hashim Muhammad Fakhrurrazi, Mohd Zaberi Nur Aina Syazana, Zheng Wei Lee, Ching Chu Beh, Jamaludin Nur Amalina, Salamt Norizam, Che Roos Nur Aishah, Ugusman Azizah
Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Cheras, Malaysia.
Faculty of Medicine and Defence Health, National Defence University of Malaysia, Kem Sungai Besi, Malaysia.
Front Physiol. 2021 Nov 23;12:742338. doi: 10.3389/fphys.2021.742338. eCollection 2021.
Skeletal muscle is one of the major tissues in the body and is important for performing daily physical activity. Previous studies suggest that vascular dysfunction contributes to reduced skeletal muscle mass. However, the association between vascular dysfunction and muscle mass, muscle strength and muscle flexibility are less established. Therefore, the focus of this review was to investigate the association between arterial stiffness (AS) which is a marker of vascular function, and muscle indices among healthy and those with cardiovascular risk factors. Three databases were used to search for relevant studies. These keywords were used: "arterial stiffness" OR "vascular stiffness" OR "aortic stiffness" OR "pulse wave velocity" OR "carotid femoral pulse wave velocity" OR "pulse wave analysis" AND "muscle" OR "skeletal" OR "flexibility" OR "range of motion" OR "articular" OR "arthrometry" OR "strength" OR "hand strength" OR "pinch strength" OR "mass" OR "lean" OR "body composition." The criteria were; (1) original, full-text articles, (2) articles written in English language, (3) human studies involving healthy adults and/or adults with cardiovascular disease (CVD) or CVD risk factors (4) articles that reported the relationship between AS (measured as carotid-femoral pulse wave velocity or brachial-ankle pulse wave velocity) and muscle indices (measured as muscle mass, muscle flexibility and muscle strength) after adjusting for relevant confounders. The search identified 2295 articles published between 1971 and June 2021. Only 17 articles fulfilled the criteria. Two studies showed an inverse association between AS and muscle strength in healthy subjects, whereas in subjects with CVD risk factors, five out of seven studies found an inverse correlation between the two parameters. Eleven studies showed an inverse association between AS and muscle mass in subjects with CVD and CVD risk factors. The association between AS and muscle flexibility was not studied in any of the articles reviewed. In conclusion, there is an inverse correlation between muscle indices and AS in healthy adults and those with CVD or CVD risk factors. However, most of the studies were cross-sectional studies, hence the need for future prospective studies to address this issue.
骨骼肌是人体主要组织之一，对日常身体活动至关重要。先前的研究表明，血管功能障碍会导致骨骼肌质量下降。然而，血管功能障碍与肌肉质量、肌肉力量和肌肉柔韧性之间的关联尚未明确。因此，本综述的重点是研究作为血管功能标志物的动脉僵硬度（AS）与健康人群以及有心血管危险因素人群的肌肉指标之间的关联。使用了三个数据库来搜索相关研究。使用了以下关键词：“动脉僵硬度”或“血管僵硬度”或“主动脉僵硬度”或“脉搏波速度”或“颈股脉搏波速度”或“脉搏波分析”以及“肌肉”或“骨骼”或“柔韧性”或“活动范围”或“关节”或“关节测量”或“力量”或“手部力量”或“捏力”或“质量”或“瘦体重”或“身体成分”。纳入标准为：（1）原创全文文章；（2）英文撰写的文章；（3）涉及健康成年人和/或患有心血管疾病（CVD）或心血管疾病危险因素的成年人的人体研究；（4）在调整相关混杂因素后报告AS（以颈股脉搏波速度或臂踝脉搏波速度测量）与肌肉指标（以肌肉质量、肌肉柔韧性和肌肉力量测量）之间关系的文章。搜索共识别出1971年至2021年6月期间发表的2295篇文章。只有17篇文章符合标准。两项研究显示健康受试者中AS与肌肉力量呈负相关，而在有心血管疾病危险因素的受试者中，七项研究中有五项发现这两个参数呈负相关。十一项研究显示患有心血管疾病和心血管疾病危险因素的受试者中AS与肌肉质量呈负相关。在所审查的任何文章中均未研究AS与肌肉柔韧性之间的关联。总之，在健康成年人以及患有心血管疾病或心血管疾病危险因素的人群中，肌肉指标与AS之间存在负相关。然而，大多数研究都是横断面研究，因此需要未来进行前瞻性研究来解决这一问题。
