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People who lack the immune protein TNF can still fight infection.

作者信息

Pyle Charlie J, Tobin David M

出版信息

Nature. 2024 Sep;633(8029):293-294. doi: 10.1038/d41586-024-02657-2.

DOI:10.1038/d41586-024-02657-2
PMID:39198607
Abstract
摘要

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1
People who lack the immune protein TNF can still fight infection.缺乏免疫蛋白TNF的人仍然能够抵抗感染。
Nature. 2024 Sep;633(8029):293-294. doi: 10.1038/d41586-024-02657-2.
2
Novel tumor necrosis factor-knockout mice that lack Peyer's patches.缺乏派尔集合淋巴结的新型肿瘤坏死因子基因敲除小鼠。
Eur J Immunol. 2005 May;35(5):1592-600. doi: 10.1002/eji.200526119.
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TNF-α and the development of the neonatal immune system: implications for inhibitor use in pregnancy.肿瘤坏死因子-α与新生儿免疫系统的发育:对妊娠期使用抑制剂的影响。
Am J Gastroenterol. 2011 Apr;106(4):559-62. doi: 10.1038/ajg.2011.5.
4
Reactivation of tuberculosis by tumor necrosis factor neutralization.肿瘤坏死因子中和导致结核病再激活。
Eur Cytokine Netw. 2007 Mar;18(1):5-13. doi: 10.1684/ecn.2007.0083. Epub 2007 Mar 30.
5
The TNF family: only the surface has been scratched.肿瘤坏死因子家族:仅触及表面而已。
Semin Immunol. 2014 Jun;26(3):181-2. doi: 10.1016/j.smim.2014.06.002. Epub 2014 Jun 30.
6
Disseminated Mycobacterium avium infection in a child with decreased tumour necrosis factor production.一名肿瘤坏死因子产生减少的儿童发生播散性鸟分枝杆菌感染。
Eur J Pediatr. 1997 Mar;156(3):204-6. doi: 10.1007/s004310050583.
7
Tumor necrosis factor α is a risk factor for infection in peritoneal dialysis patients.肿瘤坏死因子α是腹膜透析患者感染的一个危险因素。
Korean J Intern Med. 2016 Jul;31(4):722-9. doi: 10.3904/kjim.2015.230. Epub 2016 Mar 22.
8
Lack of TNF alpha supports persistence of a plasmid encoding the bovine leukaemia virus in TNF(-/-) mice.缺乏肿瘤坏死因子α支持编码牛白血病病毒的质粒在肿瘤坏死因子基因敲除(TNF(-/-))小鼠中持续存在。
Vet Immunol Immunopathol. 2003 Mar 20;92(1-2):15-22. doi: 10.1016/s0165-2427(03)00020-5.
9
Rapid pathogenesis induced by a vesicular stomatitis virus matrix protein mutant: viral pathogenesis is linked to induction of tumor necrosis factor alpha.由水泡性口炎病毒基质蛋白突变体诱导的快速发病机制:病毒发病机制与肿瘤坏死因子α的诱导有关。
J Virol. 2006 Jul;80(14):7028-36. doi: 10.1128/JVI.00478-06.
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Tumor necrosis factor alpha plays a central role in immune-mediated clearance of adenoviral vectors.肿瘤坏死因子α在腺病毒载体的免疫介导清除过程中发挥核心作用。
Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9814-9. doi: 10.1073/pnas.94.18.9814.

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The PE/PPE family proteins of : evolution, function, and prospects for tuberculosis control.结核分枝杆菌的PE/PPE家族蛋白:进化、功能及结核病控制前景
Front Immunol. 2025 Jun 17;16:1606311. doi: 10.3389/fimmu.2025.1606311. eCollection 2025.
2
as a model for understanding principles of mycobacterial pathogenesis.作为理解分枝杆菌致病机制原理的模型。
J Bacteriol. 2025 May 22;207(5):e0004725. doi: 10.1128/jb.00047-25. Epub 2025 Apr 30.

本文引用的文献

1
Protocol to develop human alveolar macrophage-like cells from mononuclear cells or purified monocytes for use in respiratory biology research.从单核细胞或纯化的单核细胞中开发人肺泡巨噬细胞样细胞用于呼吸生物学研究的方案。
STAR Protoc. 2024 Jun 21;5(2):103061. doi: 10.1016/j.xpro.2024.103061. Epub 2024 May 8.
2
Mendelian susceptibility to mycobacterial disease: recent discoveries.孟德尔易感性对分枝杆菌病的影响:最新发现。
Hum Genet. 2020 Jun;139(6-7):993-1000. doi: 10.1007/s00439-020-02120-y. Epub 2020 Feb 5.
3
TbD1 deletion as a driver of the evolutionary success of modern epidemic Mycobacterium tuberculosis lineages.
TbD1 缺失作为现代流行结核分枝杆菌谱系进化成功的驱动因素。
Nat Commun. 2020 Feb 4;11(1):684. doi: 10.1038/s41467-020-14508-5.
4
Global variation in bacterial strains that cause tuberculosis disease: a systematic review and meta-analysis.全球引起结核病的细菌菌株变异:系统评价和荟萃分析。
BMC Med. 2018 Oct 30;16(1):196. doi: 10.1186/s12916-018-1180-x.
5
Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections.宿主基因型特异性疗法可以优化针对分枝杆菌感染的炎症反应。
Cell. 2012 Feb 3;148(3):434-46. doi: 10.1016/j.cell.2011.12.023.
6
Tumor necrosis factor neutralization results in disseminated disease in acute and latent Mycobacterium tuberculosis infection with normal granuloma structure in a cynomolgus macaque model.在食蟹猴模型中,肿瘤坏死因子中和导致急性和潜伏性结核分枝杆菌感染出现播散性疾病,同时肉芽肿结构正常。
Arthritis Rheum. 2010 Feb;62(2):340-50. doi: 10.1002/art.27271.
7
Tumor necrosis factor signaling mediates resistance to mycobacteria by inhibiting bacterial growth and macrophage death.肿瘤坏死因子信号传导通过抑制细菌生长和巨噬细胞死亡来介导对分枝杆菌的抗性。
Immunity. 2008 Aug 15;29(2):283-94. doi: 10.1016/j.immuni.2008.06.011.
8
Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent.与英夫利昔单抗(一种肿瘤坏死因子α中和剂)相关的结核病。
N Engl J Med. 2001 Oct 11;345(15):1098-104. doi: 10.1056/NEJMoa011110.
9
Immunopathologic effects of tumor necrosis factor alpha in murine mycobacterial infection are dose dependent.肿瘤坏死因子α在小鼠分枝杆菌感染中的免疫病理效应具有剂量依赖性。
Infect Immun. 2000 Dec;68(12):6954-61. doi: 10.1128/IAI.68.12.6954-6961.2000.
10
Structural deficiencies in granuloma formation in TNF gene-targeted mice underlie the heightened susceptibility to aerosol Mycobacterium tuberculosis infection, which is not compensated for by lymphotoxin.肿瘤坏死因子基因靶向小鼠肉芽肿形成的结构缺陷是其对气溶胶结核分枝杆菌感染易感性增加的基础,而淋巴毒素无法弥补这一缺陷。
J Immunol. 1999 Mar 15;162(6):3504-11.