缺乏免疫蛋白TNF的人仍然能够抵抗感染。 - Suppr

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超能文献

People who lack the immune protein TNF can still fight infection.

作者信息

Pyle Charlie J, Tobin David M

出版信息

Nature. 2024 Sep;633(8029):293-294. doi: 10.1038/d41586-024-02657-2.

DOI:10.1038/d41586-024-02657-2

PMID:39198607

Abstract

摘要

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People who lack the immune protein TNF can still fight infection.缺乏免疫蛋白TNF的人仍然能够抵抗感染。

Nature. 2024 Sep;633(8029):293-294. doi: 10.1038/d41586-024-02657-2.

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Protocol to develop human alveolar macrophage-like cells from mononuclear cells or purified monocytes for use in respiratory biology research.从单核细胞或纯化的单核细胞中开发人肺泡巨噬细胞样细胞用于呼吸生物学研究的方案。

STAR Protoc. 2024 Jun 21;5(2):103061. doi: 10.1016/j.xpro.2024.103061. Epub 2024 May 8.

Mendelian susceptibility to mycobacterial disease: recent discoveries.孟德尔易感性对分枝杆菌病的影响：最新发现。

Hum Genet. 2020 Jun;139(6-7):993-1000. doi: 10.1007/s00439-020-02120-y. Epub 2020 Feb 5.

TbD1 deletion as a driver of the evolutionary success of modern epidemic Mycobacterium tuberculosis lineages.TbD1 缺失作为现代流行结核分枝杆菌谱系进化成功的驱动因素。

Nat Commun. 2020 Feb 4;11(1):684. doi: 10.1038/s41467-020-14508-5.

Global variation in bacterial strains that cause tuberculosis disease: a systematic review and meta-analysis.全球引起结核病的细菌菌株变异：系统评价和荟萃分析。

BMC Med. 2018 Oct 30;16(1):196. doi: 10.1186/s12916-018-1180-x.

Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections.宿主基因型特异性疗法可以优化针对分枝杆菌感染的炎症反应。

Cell. 2012 Feb 3;148(3):434-46. doi: 10.1016/j.cell.2011.12.023.

Tumor necrosis factor neutralization results in disseminated disease in acute and latent Mycobacterium tuberculosis infection with normal granuloma structure in a cynomolgus macaque model.在食蟹猴模型中，肿瘤坏死因子中和导致急性和潜伏性结核分枝杆菌感染出现播散性疾病，同时肉芽肿结构正常。

Arthritis Rheum. 2010 Feb;62(2):340-50. doi: 10.1002/art.27271.

Tumor necrosis factor signaling mediates resistance to mycobacteria by inhibiting bacterial growth and macrophage death.肿瘤坏死因子信号传导通过抑制细菌生长和巨噬细胞死亡来介导对分枝杆菌的抗性。

Immunity. 2008 Aug 15;29(2):283-94. doi: 10.1016/j.immuni.2008.06.011.

Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent.与英夫利昔单抗（一种肿瘤坏死因子α中和剂）相关的结核病。

N Engl J Med. 2001 Oct 11;345(15):1098-104. doi: 10.1056/NEJMoa011110.

Immunopathologic effects of tumor necrosis factor alpha in murine mycobacterial infection are dose dependent.肿瘤坏死因子α在小鼠分枝杆菌感染中的免疫病理效应具有剂量依赖性。

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Structural deficiencies in granuloma formation in TNF gene-targeted mice underlie the heightened susceptibility to aerosol Mycobacterium tuberculosis infection, which is not compensated for by lymphotoxin.肿瘤坏死因子基因靶向小鼠肉芽肿形成的结构缺陷是其对气溶胶结核分枝杆菌感染易感性增加的基础，而淋巴毒素无法弥补这一缺陷。

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