Tuerlinckx D, Vermylen C, Brichard B, Ninane J, Cornu G
Cliniques Universitaires Saint-Luc, Service d'Hématologie pédiatrique, Bruxelles, Belgium.
Eur J Pediatr. 1997 Mar;156(3):204-6. doi: 10.1007/s004310050583.
Disseminated atypical mycobacterium infection is essentially reported in cellular immunodeficient children. Cell-mediated immunity including cytokines like tumour necrosis factor alpha (TNF) and gamma interferon (IFN) is the most important factor allowing control of the dissemination of Mycobacterium. We report a child with disseminated Mycobacterium avium infection without classical immunodeficiency or HIV infection. Immunological studies revealed a defect of TNF production when the monocytes of the patient were primed with endotoxin (Escherichia coli).
This patient represents a further case of possible macrophage defect explaining the susceptibility to intracellular pathogens.
播散性非典型分枝杆菌感染主要见于细胞免疫缺陷儿童。包括肿瘤坏死因子α（TNF）和γ干扰素（IFN）等细胞因子在内的细胞介导免疫是控制分枝杆菌播散的最重要因素。我们报告一例播散性鸟分枝杆菌感染患儿，无经典免疫缺陷或HIV感染。免疫学研究显示，当用内毒素（大肠杆菌）刺激该患者的单核细胞时，TNF产生存在缺陷。
该患者代表了可能存在巨噬细胞缺陷的又一病例，解释了其对细胞内病原体的易感性。
