Sánchez-Martínez Lorena, González-Barrio Rocío, García-Alonso Javier, Mena Pedro, Periago María-Jesús
Department of Food Technology, Food Science and Nutrition, University of Murcia, CEIR Campus Mare Nostrum, Campus de Espinardo, 30100 Murcia, Spain.
Biomedical Reserach Institute of Murcia (IMIB-Arrixaca-UMU), University Clinical Hospital "Virgen de la Arrixaca", El Palmar, 30120 Murcia, Spain.
Antioxidants (Basel). 2024 Aug 9;13(8):973. doi: 10.3390/antiox13080973.
Menopause is a critical stage in a woman's life in which cardiometabolic alterations appear, such as insulin resistance or a predisposition to visceral fat deposits, leading to an increased risk of cardiometabolic diseases (R-CMBs). New strategies to reduce the R-CMBs in postmenopausal women using natural compounds without adverse effects are desirable. In this sense, plant-based diets rich in fruits and vegetables could play a fundamental role due to the high content of bioactive compounds found in these diets, such as (poly)phenols, known for their antioxidant, anti-inflammatory and vasodilator properties. The aim of this research was to carry out a dietary trial to evaluate the effect of the daily intake of different (poly)phenol-rich foods (PP-rich foods) for 2 months on the modulation of the main cardiometabolic risk biomarkers of postmenopausal women. The results showed a slight improvement in blood pressure (BP), lipid profile and oxidative stress, endothelial function and inflammatory biomarkers. These findings suggest that daily consumption of PP-rich foods alleviated the R-CMBs of postmenopausal women by reducing the oxidative stress and, thus, the risk of cardiovascular events; however, the magnitude of the cardioprotective effect of (poly)phenols depends on inter-individual variability.
更年期是女性生命中的一个关键阶段，在此期间会出现心脏代谢改变，如胰岛素抵抗或内脏脂肪沉积倾向，从而导致心脏代谢疾病（R-CMBs）风险增加。采用无不良影响的天然化合物来降低绝经后女性R-CMBs的新策略是很有必要的。从这个意义上说，富含水果和蔬菜的植物性饮食可能发挥重要作用，因为这些饮食中含有大量生物活性化合物，如（多）酚类，它们以其抗氧化、抗炎和血管舒张特性而闻名。本研究的目的是进行一项饮食试验，以评估连续2个月每日摄入不同富含（多）酚类食物（PP-rich食物）对绝经后女性主要心脏代谢风险生物标志物的调节作用。结果显示，血压（BP）、血脂谱、氧化应激、内皮功能和炎症生物标志物略有改善。这些发现表明，每日食用富含PP的食物可通过降低氧化应激，从而降低心血管事件风险，减轻绝经后女性的R-CMBs；然而，（多）酚类的心脏保护作用程度取决于个体差异。
