Department of Nutritional Sciences, School of Life Course & Population Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom.
Université Paris-Saclay, INRAE, MGP, 78350 Jouy-en-Josas, France.
Clin Nutr. 2022 Nov;41(11):2549-2561. doi: 10.1016/j.clnu.2022.08.024. Epub 2022 Sep 6.
Berry (poly)phenol consumption has been associated with cardioprotective benefits, however little is known on the role the gut microbiome may play on such health benefits. Our objective was to investigate the effects of aronia berry (poly)phenol consumption on cardiometabolic health and gut microbiome richness and composition in prehypertensive middle-aged men and women.
A total of 102 prehypertensive participants were included in a parallel 12-week randomized double-blind placebo-controlled trial. Volunteers were randomly allocated to daily consume an encapsulated (poly)phenol-rich aronia berry extract (Aronia, n = 51) or a matched maltodextrin placebo (Control, n = 51). Blood pressure (BP) and arterial function (office and 24 h), endothelial function (measured as flow-mediated dilation), serum biochemistry (including blood lipids), plasma and urine (poly)phenol metabolites as well as gut microbiome composition through shotgun metagenomic sequencing were monitored over the study period. Relationships between vascular outcomes, (poly)phenol metabolites and gut microbiome were investigated using an integrated multi-levels approach.
A significant improvement in arterial indices measured as augmentation index (AIx) and pulse wave velocity (PWV) was found in the Aronia compared to Control group (awake Δ PWV = -0.24 m/s; 95% CI: -0.79, -0.01 m/s, P < 0.05; 24 h peripheral Δ AIx = -6.8; -11.2, -2.3, %, P = 0.003; 24 h central Δ AIx = -3.3; -5.5, -1.0, %, P = 0.006). No changes in BP, endothelial function or blood lipids were found following the intervention. Consumption of aronia (poly)phenols led to a significant increase in gut microbiome gene richness and in the abundance of butyrate-producing species such as Lawsonibacter asaccharolyticus and Intestinimonas butyriciproducens species, compared to Control group. Results from an approach including metabolomic, metagenomic and clinical outcomes highlighted associations between aronia-derived phenolic metabolites, arterial stiffness, and gut microbiome.
Aronia berry (poly)phenol consumption improved arterial function in prehypertensive middle-aged individuals, possibly via modulation of gut microbiome richness and composition based on the associations observed between these parameters.
The National Institutes of Health (NIH)-randomized trial records held on the NIH ClinicalTrials.gov website (NCT03434574). Aronia Berry Consumption on Blood Pressure.
浆果（多）酚的摄入与心脏保护益处有关，然而，关于肠道微生物组在这种健康益处中可能发挥的作用知之甚少。我们的目的是研究黑树莓（多）酚的摄入对中年前期高血压男女的心脏代谢健康和肠道微生物组丰富度和组成的影响。
共有 102 名前期高血压患者参与了一项平行的 12 周随机双盲安慰剂对照试验。志愿者被随机分配每天服用一种封装的（多）酚富黑树莓提取物（Aronia，n=51）或匹配的麦芽糊精安慰剂（Control，n=51）。在研究期间，监测血压（BP）和动脉功能（办公室和 24 小时）、内皮功能（测量为血流介导的扩张）、血清生化（包括血脂）、血浆和尿液（多）酚代谢物以及通过 shotgun 宏基因组测序的肠道微生物组组成。使用集成的多层次方法研究血管结局、（多）酚代谢物和肠道微生物组之间的关系。
与对照组相比，Aronia 组的动脉指数（如增强指数（AIx）和脉搏波速度（PWV））有显著改善（清醒时 PWV 变化为-0.24m/s；95%CI：-0.79，-0.01m/s，P<0.05；24 小时外周 AIx 变化为-6.8；-11.2，-2.3%，P=0.003；24 小时中央 AIx 变化为-3.3；-5.5，-1.0%，P=0.006）。干预后血压、内皮功能或血脂无变化。与对照组相比，黑树莓（多）酚的摄入导致肠道微生物组基因丰富度和丁酸盐产生物种（如 Lawsonibacter asaccharolyticus 和 Intestinimonas butyriciproducens 物种）的丰度显著增加。一种包括代谢组学、宏基因组学和临床结果的方法的结果强调了黑树莓衍生的酚类代谢物与动脉僵硬之间的关联，以及肠道微生物组。
黑树莓（多）酚的摄入改善了中年前期高血压个体的动脉功能，这可能是通过调节肠道微生物组的丰富度和组成来实现的，这是基于观察到的这些参数之间的关联。
美国国立卫生研究院（NIH）-随机试验记录在美国国立卫生研究院临床试验.gov 网站上（NCT03434574）。黑树莓浆果对血压的影响。
