Ghaziri Jimmy, Fei Phillip, Tucholka Alan, Obaid Sami, Boucher Olivier, Rouleau Isabelle, Nguyen Dang K
Département de Psychologie, Université du Québec à Montréal, Montréal, QC H2X 3P2, Canada.
Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC H2X 0A9, Canada.
Brain Sci. 2024 Jul 25;14(8):742. doi: 10.3390/brainsci14080742.
The insula is often considered the fifth lobe of the brain and is increasingly recognized as one of the most connected regions in the brain, with widespread connections to cortical and subcortical structures. As a follow-up to our previous tractography work, we investigated the resting-state functional connectivity (rsFC) profiles of insular subregions and assessed their concordance with structural connectivity. We used the CONN toolbox to analyze the rsFC of the same 19 insular regions of interest (ROIs) we used in our prior tractography work and regrouped them into six subregions based on their connectivity pattern similarity. Our analysis of 50 healthy participants confirms the known broad connectivity of the insula and shows novel and specific whole-brain and intra-connectivity patterns of insular subregions. By examining such subregions, our findings provide a more detailed pattern of connectivity than prior studies that may prove useful for comparison between patients.
脑岛通常被认为是大脑的第五叶，并且越来越被视为大脑中连接最为广泛的区域之一，与皮质和皮质下结构有着广泛的连接。作为我们之前纤维束成像工作的后续研究，我们调查了脑岛亚区域的静息态功能连接（rsFC）概况，并评估了它们与结构连接的一致性。我们使用CONN工具包分析了我们之前纤维束成像工作中使用的相同19个脑岛感兴趣区域（ROI）的rsFC，并根据它们的连接模式相似性将它们重新划分为六个亚区域。我们对50名健康参与者的分析证实了脑岛已知的广泛连接性，并显示了脑岛亚区域新颖且特定的全脑和内部连接模式。通过检查这些亚区域，我们的研究结果提供了比以往研究更详细的连接模式，这可能对患者之间的比较有用。
