Département de psychologie, Université du Québec à Montréal, Montréal, Qc, Canada.
Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, Qc, Canada.
Sci Rep. 2018 Jun 5;8(1):8596. doi: 10.1038/s41598-018-26995-0.
Hidden beneath the Sylvian fissure and sometimes considered as the fifth lobe of the brain, the insula plays a multi-modal role from its strategic location. Previous structural studies have reported cortico-cortical connections with the frontal, temporal, parietal and occipital lobes, but only a few have looked at its connections with subcortical structures. The insular cortex plays a role in a wide range of functions including processing of visceral and somatosensory inputs, olfaction, audition, language, motivation, craving, addiction and emotions such as pain, empathy and disgust. These functions implicate numerous subcortical structures, as suggested by various functional studies. Based on these premises, we explored the structural connectivity of insular ROIs with the thalamus, amygdala, hippocampus, putamen, globus pallidus, caudate nucleus and nucleus accumbens. More precisely, we were interested in unraveling the specific areas of the insula connected to these subcortical structures. By using state-of-the-art HARDI tractography algorithm, we explored here the subcortical connectivity of the insula.
隐藏在大脑外侧裂下方，有时被认为是大脑的第五个脑叶，脑岛从其战略位置发挥着多模态作用。以前的结构研究报告了与额叶、颞叶、顶叶和枕叶的皮质-皮质连接，但只有少数研究关注其与皮质下结构的连接。脑岛皮层在广泛的功能中发挥作用，包括内脏和躯体感觉输入、嗅觉、听觉、语言、动机、渴望、成瘾和情绪（如疼痛、同理心和厌恶）的处理。这些功能暗示了许多皮质下结构，正如各种功能研究所表明的那样。基于这些前提，我们探索了岛叶 ROI 与丘脑、杏仁核、海马体、壳核、苍白球、尾状核和伏隔核的结构连接。更准确地说，我们感兴趣的是解开与这些皮质下结构相连的岛叶的特定区域。通过使用最先进的 HARDI 束追踪算法，我们在这里探索了岛叶的皮质下连接。
