Zanelli Gustavo Ricci, Vieira Gabriela Brambilo Menegasso, Souza Rafaela Vitória Marchini, Aguiar Antonio José de Araújo, Cassu Renata Navarro
Department of Veterinary Surgery and Anesthesiology, Faculty of Veterinary Medicine, Universidade do Oeste Paulista (UNOESTE), Presidente Prudente 19067-175, Brazil.
Department of Veterinary Surgery and Animal Reproduction, Faculdade de Medicina Veterinária e Zootecnia, Universidade Estadual Paulista (UNESP), Botucatu 18618-681, Brazil.
Animals (Basel). 2024 Aug 6;14(16):2286. doi: 10.3390/ani14162286.
The aim of this study was to evaluate the perioperative analgesic and sedative effects of oral CBD in cats undergoing ovariohysterectomy. Twenty-two cats were assigned to receive either oral cannabidiol oil (2 mg/kg, CBD group, = 12) or placebo oil (0.1 mL/kg, Placebo group, = 10) 60 min before the premedication. The anesthetic protocol included dexmedetomidine/meperidine, propofol, and isoflurane. Intravenous fentanyl was given to control cardiovascular responses to surgical stimulation. Pain was assessed at 0.5, 1, 2, 4, 6 and 8 h post-extubation using the UNESP-Botucatu multidimensional composite pain scale and the Glasgow feline composite-measure pain scale. Sedation scores were assessed at the same timepoints and at 15 min after the premedication. Morphine was administered as rescue analgesia. Higher sedation scores were recorded in the CBD group at 15 min after premedication ( = 0.041). Intraoperatively, more cats required fentanyl in the Placebo group than in CBD group ( = 0.028). The pain scores did not differ between groups, except at 0.5 h post-extubation when lower scores were detected in the CBD group ( = 0.003-0.005). Morphine was required in 100% of the animals in both groups. CBD increased preoperative sedation and decreased intraoperative analgesic requirements, with minimal evidence of postoperative analgesic benefits over the placebo.
本研究的目的是评估口服大麻二酚（CBD）对接受卵巢子宫切除术的猫的围手术期镇痛和镇静效果。22只猫在术前60分钟被分配接受口服大麻二酚油（2mg/kg，CBD组，n = 12）或安慰剂油（0.1mL/kg，安慰剂组，n = 10）。麻醉方案包括右美托咪定/哌替啶、丙泊酚和异氟烷。静脉注射芬太尼以控制手术刺激引起的心血管反应。使用圣保罗大学-博图卡图多维综合疼痛量表和格拉斯哥猫综合测量疼痛量表在拔管后0.5、1、2、4、6和8小时评估疼痛。在相同时间点以及术前用药后15分钟评估镇静评分。给予吗啡作为急救镇痛。CBD组在术前用药后15分钟的镇静评分更高（P = 0.041）。术中，安慰剂组比CBD组更多的猫需要芬太尼（P = 0.028）。除了拔管后0.5小时CBD组疼痛评分较低外（P = 0.003 - 0.005），两组之间的疼痛评分没有差异。两组100%的动物都需要吗啡。CBD增加了术前镇静并降低了术中镇痛需求，与安慰剂相比，术后镇痛益处的证据极少。
