Ruggieri A P, Galbraith R M, Lazarchick J
Clin Exp Rheumatol. 1985 Jan-Mar;3(1):71-3.
A patient with an acquired immune deficiency syndrome developed a lupus anticoagulant in which the inhibitory activity was manifested only as a prolongation of the partial thromboplastin time. Contrary to previous reports, the substitution of platelets or platelet sonicates for phospholipid in this coagulant assay failed to correct the abnormality and the inhibitor did not exhibit immunoreactivity against phospholipids. The possible mechanisms of action of these inhibitors are discussed.
一名获得性免疫缺陷综合征患者出现狼疮抗凝物，其抑制活性仅表现为部分凝血活酶时间延长。与先前的报道相反，在这种凝血试验中用血小板或血小板超声提取物替代磷脂未能纠正异常，且该抑制剂对磷脂无免疫反应性。文中讨论了这些抑制剂可能的作用机制。
