Yu Jiang-Zhou, Zhou Jun, Yang Fang-Xi, Hao Jin-Ping, Hou Zhuo-Cheng, Zhu Feng
National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics, Breeding and Reproduction of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Beijing Nankou Duck Breeding Technology Co., Ltd., Beijing 102202, China.
Animals (Basel). 2024 Aug 14;14(16):2349. doi: 10.3390/ani14162349.
Body size is an important growth indicator in ducks and is a primary selection criterion for physical improvement. An excessively rapid growth rate in meat ducks can result in excessive body size, which may hinder subsequent processing and slaughter operations. However, only a few molecular markers related to body size have been studied in meat ducks. In this study, we performed a genome-wide association study (GWAS) to identify candidate genes and QTLs affecting body length (BL), keel bone length (KBL), neck length (NL), and breast width (BrW) in Pekin ducks (Anas platyrhynchos domestica). Our results indicate the significant SNP for NL is located within a pseudogene, whereas the significant SNP for BrW is located in an intergenic region. More importantly, our analysis identified a haplotype that was significantly associated with both BL and KBL. This haplotype, containing 48 single-nucleotide polymorphisms (SNPs), is localized within the gene. The identification of this haplotype suggests that may be a key candidate gene influencing BL and KBL in Pekin ducks. These findings have important implications for the breeding and genetic improvement of Pekin ducks, and provide valuable insights into the genetic architecture of body size traits in this species.
体型是鸭生长的重要指标，也是鸭体改良的主要选择标准。肉鸭生长速度过快会导致体型过大，这可能会妨碍后续的加工和屠宰操作。然而，在肉鸭中，只有少数与体型相关的分子标记得到了研究。在本研究中，我们进行了全基因组关联研究（GWAS），以鉴定影响北京鸭（Anas platyrhynchos domestica）体长（BL）、龙骨长（KBL）、颈长（NL）和胸宽（BrW）的候选基因和数量性状位点（QTL）。我们的结果表明，NL的显著单核苷酸多态性（SNP）位于一个假基因内，而BrW的显著SNP位于基因间区域。更重要的是，我们的分析鉴定出一个与BL和KBL均显著相关的单倍型。这个包含48个单核苷酸多态性（SNP）的单倍型位于 基因内。该单倍型的鉴定表明， 可能是影响北京鸭BL和KBL的关键候选基因。这些发现对北京鸭的育种和遗传改良具有重要意义，并为该物种体型性状的遗传结构提供了有价值的见解。
