Huang Lan, Sun Jialuo, Guo Qixin, Jiang Yong, Hao Bai, Chang Guobin
Key Laboratory for Animal Genetics & Molecular Breeding of Jiangsu Province, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Institutes of Agricultural Science and Technology Development, Yangzhou University, Yangzhou 225009, China.
Animals (Basel). 2024 Aug 18;14(16):2395. doi: 10.3390/ani14162395.
To investigate the effects of early administration of ciprofloxacin (CIP) on Xueshan chickens, in this study Xueshan chickens were measured for growth performance, tested for drug residues, evaluated for meat quality, and muscle metabolism changes were explored using a non-target metabolomics approach. Experimental findings revealed that early CIP use did not significantly impact the overall growth rate of Xueshan chickens ( > 0.05). However, notable alterations in meat quality were observed: the CIP-treated group exhibited a significant decrease in muscle pH (pH and pH) and a marked increase in drip loss and moisture content ( > 0.05). No CIP residues were detected in muscle tissue. Untargeted metabolomics analyses unveiled significant alterations in the metabolic profile of market-age chickens following CIP treatment. Both functional enrichment and metabolic network analyses indicated significant effects on the ko01120 (microbial metabolism in diverse environments) and ko00350 (tyrosine metabolism) pathways, implying that CIP treatment may influence chicken meat quality by modulating microbial communities and amino acid metabolism. This study provides a crucial foundation for understanding the impact of antibiotics on meat quality and metabolism in poultry production, offering scientific insights for optimizing antibiotic-use strategies and safeguarding poultry product quality.
为了研究早期给予环丙沙星（CIP）对雪山鸡的影响，本研究对雪山鸡的生长性能进行了测定，检测了药物残留，评估了肉质，并采用非靶向代谢组学方法探究了肌肉代谢变化。实验结果表明，早期使用CIP对雪山鸡的总体生长速率没有显著影响（>0.05）。然而，观察到肉质有显著变化：CIP处理组的肌肉pH值（pH和pH）显著降低，滴水损失和水分含量显著增加（>0.05）。在肌肉组织中未检测到CIP残留。非靶向代谢组学分析揭示了CIP处理后上市龄鸡代谢谱的显著变化。功能富集和代谢网络分析均表明对ko01120（不同环境中的微生物代谢）和ko00350（酪氨酸代谢）途径有显著影响，这意味着CIP处理可能通过调节微生物群落和氨基酸代谢来影响鸡肉品质。本研究为理解抗生素对家禽生产中肉质和代谢的影响提供了重要基础，为优化抗生素使用策略和保障禽产品质量提供了科学见解。
