Stearns Kaylen, DelCurto-Wyffels Hannah, Wyffels Sam, Van Emon Megan, DelCurto Tim
Department of Animal Science, Montana State University, Bozeman, MT 59717, USA.
Animals (Basel). 2024 Aug 22;14(16):2430. doi: 10.3390/ani14162430.
Pulmonary arterial pressure (PAP) determines cattle's susceptibility to High Altitude Disease (HAD), also known as Brisket Disease, High Mountain Disease, and right-sided heart failure (RHF). This non-infectious disease causes pulmonary hypertension due to hypoxia. PAP measures the resistance of blood flow through the lungs. It is estimated that 1.5 million head of cattle are raised in high-altitude environments (above 1500 m), and HAD accounts for 3-5% of calf death loss yearly. In addition, there have been increasing concerns about feedlot cattle succumbing to RHF at moderate elevations. This review focuses on the historical background, explanation of PAP measurement and scores, genetic implications, and the relationship between PAP and economically relevant traits. Specifically, traits such as gestation length, birth weight, weaning weight, and yearling weight may impact PAP scores. In addition, environmental effects and other factors impacting PAP score variations are discussed. Information gaps and research needs are addressed to determine where missing information could improve the understanding of PAP while also benefiting beef cattle producers in high-elevation production systems.
肺动脉压（PAP）决定了牛对高原病（HAD）的易感性，高原病也被称为胸肉病、高山病和右侧心力衰竭（RHF）。这种非传染性疾病由于缺氧导致肺动脉高压。PAP测量血液流经肺部的阻力。据估计，有150万头牛在高海拔环境（海拔1500米以上）饲养，HAD每年占犊牛死亡损失的3%-5%。此外，越来越多的人担心饲养场的牛在中等海拔地区死于RHF。本综述重点关注历史背景、PAP测量和评分的解释、遗传影响以及PAP与经济相关性状之间的关系。具体而言，妊娠期长度、出生体重、断奶体重和周岁体重等性状可能会影响PAP评分。此外，还讨论了环境影响和其他影响PAP评分变化的因素。解决了信息差距和研究需求，以确定哪些缺失信息可以增进对PAP的理解，同时也使高海拔生产系统中的肉牛生产者受益。
