Petakh Pavlo, Poliak Mykhailo, Kohutych Anton, Oksenych Valentyn, Kamyshnyi Oleksandr
Department of Biochemistry and Pharmacology, Uzhhorod National University, 88000 Uzhhorod, Ukraine.
Department of Microbiology, Virology and Immunology, I. Horbachevsky Ternopil National Medical University, 46001 Ternopil, Ukraine.
Biomedicines. 2024 Jul 29;12(8):1685. doi: 10.3390/biomedicines12081685.
Leptospirosis presents a significant health challenge in the Transcarpathian region of Ukraine, with higher incidence rates and mortality compared to national averages. We conducted a retrospective cohort study to investigate the effects of antibiotic and steroid treatments on outcomes in leptospirosis patients. Our analysis of clinical and laboratory data from a single center revealed that dexamethasone showed significant effects on various clinical variables, as did investigated antibiotics. Notable differences in clinical and laboratory outcomes were observed, particularly in direct bilirubin levels, which were significantly higher in non-survivors. ROC analysis demonstrated high sensitivity and specificity of direct bilirubin as a predictor of mortality. These findings highlight the importance of targeted treatment strategies and the potential of specific laboratory markers in improving leptospirosis management.
钩端螺旋体病在乌克兰外喀尔巴阡地区构成了重大的健康挑战，其发病率和死亡率高于全国平均水平。我们进行了一项回顾性队列研究，以调查抗生素和类固醇治疗对钩端螺旋体病患者预后的影响。我们对来自单一中心的临床和实验室数据的分析表明，地塞米松对各种临床变量有显著影响，所研究的抗生素也是如此。观察到临床和实验室结果存在显著差异，特别是直接胆红素水平，非幸存者的直接胆红素水平显著更高。ROC分析表明直接胆红素作为死亡率预测指标具有高敏感性和特异性。这些发现凸显了针对性治疗策略的重要性以及特定实验室标志物在改善钩端螺旋体病管理方面的潜力。
