Mastrangelo Stefano, Peruzzi Laura, Guido Antonella, Iuvone Laura, Attinà Giorgio, Romano Alberto, Maurizi Palma, Chieffo Daniela Pia Rosaria, Ruggiero Antonio
Pediatric Oncology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
Department of Woman and Child Health and Public Health, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Biomedicines. 2024 Aug 1;12(8):1707. doi: 10.3390/biomedicines12081707.
Over the last several years, a growing body of evidence from anatomical, physiological, and functional neuroimaging studies has increasingly indicated that the cerebellum is actively involved in managing higher order cognitive functions and regulating emotional responses. It has become clear that when children experience congenital or acquired cerebellar lesions, these injuries can lead to a variety of cognitive and emotional disorders, manifesting in different combinations. This underscores the cerebellum's essential role not only throughout developmental stages but particularly in facilitating learning processes, highlighting its critical importance beyond its traditional association with motor control. Furthermore, the intricate neural circuits within the cerebellum are believed to contribute to the fine-tuning of motor actions and coordination but are also increasingly recognized for their involvement in cognitive processes such as attention, language, and problem solving. Recent research has highlighted the importance of cerebellar health and integrity for optimal functioning across various domains of the human experience.
在过去几年中，来自解剖学、生理学和功能性神经影像学研究的越来越多的证据日益表明，小脑积极参与管理高阶认知功能并调节情绪反应。很明显，当儿童经历先天性或后天性小脑损伤时，这些损伤会导致各种认知和情绪障碍，以不同的组合表现出来。这突出了小脑不仅在整个发育阶段，而且特别是在促进学习过程中的重要作用，凸显了其超越传统上与运动控制关联的至关重要性。此外，小脑内复杂的神经回路被认为有助于运动动作的微调与协调，但它们在诸如注意力、语言和解决问题等认知过程中的参与也越来越受到认可。最近的研究强调了小脑健康与完整性对于人类体验各个领域最佳功能的重要性。
