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通过大鼠的肌肉周围/肌肉内和皮下植入评估复合水泥的生物相容性。

Assessing Biocompatibility of Composite Cements by Peri/Intramuscular and Subcutaneous Implantation in Rats.

作者信息

Ardelean Alina Ioana, Marza Sorin Marian, Negoescu Andrada, Dragomir Madalina Florina, Sarosi Codruta, Moldovan Marioara, Ene Razvan, Oana Liviu

机构信息

Department of Veterinary Surgery, Faculty of Veterinary Medicine, University of Agricultura Sciencies and Veterinary Medicine, 400372 Cluj-Napoca, Romania.

Department of Veterinary Imagistics, Faculty of Veterinary Medicine, University of Agricultura Sciencies and Veterinary Medicine, 400372 Cluj-Napoca, Romania.

出版信息

Biomedicines. 2024 Aug 1;12(8):1718. doi: 10.3390/biomedicines12081718.

DOI:10.3390/biomedicines12081718
PMID:39200185
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11351888/
Abstract

This study's goal was to evaluate the biocompatibility of two composite cements over a 90-day period by analyzing the individuals' behavior as well as conducting macroscopic and histological examinations and Computed Tomography (CT) scans. We conducted the cytotoxicity test by placing the materials subcutaneously and peri/intramuscularly. Days 30 and 90 were crucial for our research. On those days, we harvested the implants, kidneys and liver to search for any toxic deposits. The biomaterial's uniformity, color and texture remained unaltered despite being in intimate contact with the tissue. Although a slight inflammatory response was observed in the placement location, we observed an improved outcome of the interaction between the material and its insertion area. There were no notable discoveries in the liver and kidneys. According to the obtained results, the biomaterials did not produce any clinical changes nor specific irritation during the research, demonstrating that they are biocompatible with biological tissues.

摘要

本研究的目的是通过分析个体的行为、进行宏观和组织学检查以及计算机断层扫描（CT），在90天的时间内评估两种复合骨水泥的生物相容性。我们通过将材料皮下、肌肉周围/肌肉内放置来进行细胞毒性试验。第30天和第90天对我们的研究至关重要。在这些日子里，我们取出植入物、肾脏和肝脏以寻找任何有毒沉积物。尽管生物材料与组织紧密接触，但其均匀性、颜色和质地仍未改变。虽然在放置部位观察到轻微的炎症反应，但我们观察到材料与其植入区域之间相互作用的结果有所改善。在肝脏和肾脏中未发现明显异常。根据获得的结果，生物材料在研究期间未产生任何临床变化或特定刺激，表明它们与生物组织具有生物相容性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba65/11351888/72c2e8e9685f/biomedicines-12-01718-g011.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba65/11351888/9d139dc12b9b/biomedicines-12-01718-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba65/11351888/1fa1ffb08552/biomedicines-12-01718-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba65/11351888/1b6db4b6b2c9/biomedicines-12-01718-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba65/11351888/f976972db50c/biomedicines-12-01718-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba65/11351888/ebc21cb50892/biomedicines-12-01718-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba65/11351888/72c2e8e9685f/biomedicines-12-01718-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba65/11351888/ea869d046676/biomedicines-12-01718-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba65/11351888/19ef3efaaafe/biomedicines-12-01718-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba65/11351888/ab8994c41d17/biomedicines-12-01718-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba65/11351888/6d6c94b7e17e/biomedicines-12-01718-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba65/11351888/67f1e9b22995/biomedicines-12-01718-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba65/11351888/9d139dc12b9b/biomedicines-12-01718-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba65/11351888/1fa1ffb08552/biomedicines-12-01718-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba65/11351888/1b6db4b6b2c9/biomedicines-12-01718-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba65/11351888/f976972db50c/biomedicines-12-01718-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba65/11351888/ebc21cb50892/biomedicines-12-01718-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba65/11351888/72c2e8e9685f/biomedicines-12-01718-g011.jpg

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