Koirala Mahesh, DiPaola Mario
Therabene Inc., Norwood, MA 02062, USA.
Biomedicines. 2024 Aug 8;12(8):1801. doi: 10.3390/biomedicines12081801.
Resistance to cancer drugs is a complex phenomenon that poses a significant challenge in the treatment of various malignancies. This review comprehensively explores cancer resistance mechanisms and discusses emerging strategies and modalities to overcome this obstacle. Many factors contribute to cancer resistance, including genetic mutations, activation of alternative signaling pathways, and alterations in the tumor microenvironment. Innovative approaches, such as targeted protein degradation, immunotherapy combinations, precision medicine, and novel drug delivery systems, hold promise for improving treatment outcomes. Understanding the intricacies of cancer resistance and leveraging innovative modalities are essential for advancing cancer therapy.
对癌症药物的耐药性是一种复杂的现象，在各种恶性肿瘤的治疗中构成了重大挑战。本综述全面探讨了癌症耐药机制，并讨论了克服这一障碍的新兴策略和方式。许多因素导致癌症耐药，包括基因突变、替代信号通路的激活以及肿瘤微环境的改变。创新方法，如靶向蛋白降解、免疫治疗联合、精准医学和新型药物递送系统，有望改善治疗效果。了解癌症耐药的复杂性并利用创新方式对于推进癌症治疗至关重要。
