Department of Biology, Faculty of Arts and Sciences, Holy Spirit University of Kaslik, Jounieh P.O. Box 446, Lebanon.
UMR Inserm 1253 Ibrain, Université de Tours, 37032 Tours, France.
Int J Environ Res Public Health. 2024 Aug 5;21(8):1027. doi: 10.3390/ijerph21081027.
Attention-Deficit/Hyperactivity Disorder (ADHD), a prevalent childhood neurodevelopmental disorder with complex etiology involving genetic and environmental factors, causes impairments across various life domains and substantial social and economic burden. Identifying correlates to prevent its onset and decrease its incidence is crucial. To our knowledge, our study represents the first case-control investigation of Lebanese ADHD patients to explore potential correlations between familial, maternal, and child health variables and ADHD to enhance understanding of its etiology and aid in prevention efforts. We recruited 61 Lebanese ADHD patients and 58 matched controls aged 6-24 years from all districts of Lebanon. The data to analyze were collected using a questionnaire. We employed statistical tests, including the independent samples -test and the Chi-square test or Fisher's exact test. We conducted a multivariate logistic regression analysis to identify the statistically significant factors explaining ADHD likelihood. We observed male predominance (68.9%) among patients. Maternal anemia during pregnancy (OR = 3.654; 95% CI [1.158-11.529]), maternal self-reported stress during pregnancy (OR = 3.268; 95% CI [1.263-8.456]), neonatal jaundice (OR = 5.020; 95% CI [1.438-17.532]), and familial history of ADHD (OR = 12.033; 95% CI [2.950-49.072]) were significantly associated with increased odds of the disorder. On the other hand, breastfeeding (OR = 0.263; 95% CI [0.092-0.757]) was identified as a protective factor against ADHD. This pilot study shed light on risk and protective factors associated with ADHD in the Lebanese population. The results are relevant, as some identified correlates could be avoidable. Further rigorous investigation is required to expand upon the observed correlations and to assist in early detection, prevention, and intervention strategies targeting ADHD.
注意缺陷多动障碍(ADHD)是一种常见的儿童神经发育障碍,其病因复杂,涉及遗传和环境因素,会导致患者在各个生活领域出现障碍,并带来巨大的社会和经济负担。确定相关因素以预防其发病和降低其发病率至关重要。据我们所知,我们的研究代表了对黎巴嫩 ADHD 患者的首例病例对照研究,旨在探索家族、产妇和儿童健康变量与 ADHD 之间的潜在相关性,以加深对其病因的理解,并为预防工作提供帮助。我们招募了 61 名黎巴嫩 ADHD 患者和 58 名年龄在 6-24 岁的匹配对照者,他们来自黎巴嫩的所有地区。使用问卷收集分析数据。我们采用了统计学检验,包括独立样本 t 检验、卡方检验或 Fisher 精确检验。我们进行了多变量逻辑回归分析,以确定解释 ADHD 可能性的统计学显著因素。我们观察到患者中男性占主导地位(68.9%)。妊娠期间母亲贫血(OR = 3.654;95%CI [1.158-11.529])、妊娠期间母亲自我报告的压力(OR = 3.268;95%CI [1.263-8.456])、新生儿黄疸(OR = 5.020;95%CI [1.438-17.532])和家族 ADHD 病史(OR = 12.033;95%CI [2.950-49.072])与该疾病的发病几率增加显著相关。另一方面,母乳喂养(OR = 0.263;95%CI [0.092-0.757])被确定为 ADHD 的保护因素。这项初步研究揭示了与黎巴嫩人群 ADHD 相关的风险和保护因素。这些结果具有相关性,因为一些确定的相关因素是可以避免的。需要进一步进行严格的研究,以扩展观察到的相关性,并为 ADHD 的早期发现、预防和干预策略提供帮助。