are with the Maternal, Child and Adolescent Health Program, Burnet Institute, Melbourne, Victoria, Australia.
are with the Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Nutr Rev. 2023 Mar 10;81(4):480-491. doi: 10.1093/nutrit/nuac066.
Iron deficiency anemia in pregnancy is a major public health problem known to cause maternal morbidity and adverse birth outcomes, and it may also have lasting consequences on infant development. However, the impact of the maternal hematological environment on fetal and infant hemoglobin and iron stores in the first year of life remains unclear. This review of the epidemiological evidence found that severe maternal iron deficiency anemia in pregnancy is associated with lower ferritin, and to a lesser degree hemoglobin levels, in infants at birth. Emerging data also suggests that severe anemia in pregnancy increases the risk of iron deficiency and anemia in infants 6-12 months of age, although longitudinal studies are limited. Effective anemia prevention in pregnancy, such as iron supplementation, could reduce the risk of infant anemia and iron deficiency during the first year of life; however, more evidence is needed to determine the functional impact of iron supplementation in pregnancy on infant hematological indices.
妊娠期缺铁性贫血是一个主要的公共卫生问题，已知会导致产妇发病率和不良出生结局，并且可能对婴儿发育产生持久影响。然而，母体血液环境对胎儿和婴儿在生命的第一年血红蛋白和铁储存的影响仍不清楚。对流行病学证据的综述发现，妊娠期间严重的母体缺铁性贫血与婴儿出生时铁蛋白水平较低相关，血红蛋白水平的相关性则较低。新出现的数据还表明，妊娠期间严重贫血增加了婴儿 6-12 月龄时缺铁和贫血的风险，尽管纵向研究有限。有效的妊娠期贫血预防，如铁补充，可以降低婴儿在生命的第一年发生贫血和缺铁的风险；然而，还需要更多的证据来确定妊娠期间铁补充对婴儿血液学指标的功能影响。
