Littman B A, Hodgen G D
Fertil Steril. 1985 Mar;43(3):463-70. doi: 10.1016/s0015-0282(16)48450-5.
Despite the increasing use of clomiphene citrate (CC) in normally cycling women undergoing in vitro fertilization, comprehensive data on the dose-response effects of the drug are unavailable. Twenty-four adult, normally cycling monkeys were given CC on cycle days 5 through 9 in doses ranging from 1 mg/kg to 10 mg/kg. Serum estradiol (E2), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and progesterone were measured daily. CC stimulated an early, attenuated rise in serum LH which correlated with subsequent follicle development. Concurrently, serum E2 rose to preovulatory levels. No significant increase in serum FSH concentration was seen as a result of CC therapy. No correlation was seen between CC dose and peak levels of E2, LH, or FSH. The ovulatory status of the treatment cycles was also independent of dose. The factors that modulate these hormonal changes may involve direct effects of CC, estrogen feedback, and/or ovarian factors as yet uncharacterized. The individual variation of ovarian response, however, appears to be independent of the dose of CC.
尽管枸橼酸氯米芬（CC）在接受体外受精的月经周期正常的女性中使用越来越多，但关于该药物剂量反应效应的全面数据却并不存在。24只成年、月经周期正常的猴子在周期第5至9天给予CC，剂量范围为1毫克/千克至10毫克/千克。每天测量血清雌二醇（E2）、黄体生成素（LH）、卵泡刺激素（FSH）和孕酮。CC刺激血清LH早期出现减弱的升高，这与随后的卵泡发育相关。同时，血清E2升至排卵前水平。CC治疗未导致血清FSH浓度显著增加。CC剂量与E2、LH或FSH的峰值水平之间未发现相关性。治疗周期的排卵状态也与剂量无关。调节这些激素变化的因素可能涉及CC的直接作用、雌激素反馈和/或尚未明确的卵巢因素。然而，卵巢反应的个体差异似乎与CC剂量无关。
