Chryssikopoulos A, Antoniou A, Kassanos D, Vazoura E
2nd Department of Obstetrics and Gynecology, University of Athens, Aretaiion Hospital, Greece.
Int J Gynaecol Obstet. 1988 Apr;26(2):271-7. doi: 10.1016/0020-7292(88)90273-1.
Sixty-eight anovulatory women were divided into three groups according to the administered doses of clomiphene citrate (CC) (A 250 mg, B 500 mg, C 750 mg). Daily follicle-stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E2) measurements were performed. Follicular maturation was monitored by ultrasound. In the high-CC dose group, a statistically significant FSH rise was noted. As a result, earlier selection of the dominant follicle (DF), faster increase in the DF diameter and increased E2 production was found.
