Georgoudas Michael, Moraitou Despina, Poptsi Eleni, Tsardoulias Emmanouil, Kesanli Despina, Papaliagkas Vasileios, Tsolaki Magda
IPPS "Neuroscience and Neurodegeneration", Faculty of Medicine, Aristotle University of Thessaloniki (AUTh), 54124 Thessaloniki, Greece.
Laboratory of Psychology, Department of Cognition, Brain and Behavior, School of Psychology, Aristotle University of Thessaloniki (AUTh), 54124 Thessaloniki, Greece.
Healthcare (Basel). 2024 Aug 14;12(16):1622. doi: 10.3390/healthcare12161622.
The importance of night sleep for maintaining good physical and cognitive health is well documented as well as its negative changes during aging. Since Mild Cognitive Impairment (MCI) patients bear additional disturbances in their sleep, this study aimed at examining whether there are potential mixed effects of sleep and afternoon time of day (ToD) on the storage, processing, and updating components of working memory (WM) capacity in older adults with MCI. In particular, the study compared patients' performance in the three working memory components, in two-time conditions: "early in the morning and after night sleep", and "in the afternoon and after many hours since night sleep". The Working Memory Capacity & Updating Task from the R4Alz battery was administered twice to 50 older adults diagnosed with MCI. The repeated measures analysis showed statistically significant higher performance in the morning condition for the working memory updating component ( < 0.001). Based on the findings, it seems that the afternoon ToD condition negatively affects tasks with high cognitive demands such as the WM updating task in MCI patients. These findings could determine the optimal timing for cognitive rehabilitation programs for MCI patients and the necessary sleep duration when they are engaged in cognitively demanding daily activities.
夜间睡眠对维持良好的身体和认知健康的重要性已得到充分证明，其在衰老过程中的负面变化也是如此。由于轻度认知障碍（MCI）患者的睡眠存在额外干扰，本研究旨在探讨睡眠和下午时间（ToD）对MCI老年患者工作记忆（WM）容量的存储、处理和更新成分是否存在潜在的混合影响。具体而言，该研究比较了患者在两种时间条件下三个工作记忆成分的表现：“清晨和夜间睡眠后”以及“下午和夜间睡眠数小时后”。对50名被诊断为MCI的老年人，两次实施了R4Alz电池组中的工作记忆容量与更新任务。重复测量分析显示，在早晨条件下，工作记忆更新成分的表现具有统计学意义上的显著提高（<0.001）。基于这些发现，似乎下午的ToD条件对诸如MCI患者的WM更新任务等高认知需求任务产生负面影响。这些发现可以确定MCI患者认知康复计划的最佳时间，以及他们从事高认知需求日常活动时所需的睡眠时间。
