新阐释的血管生成出芽、套叠、旋曲和融合等类型。

New Interpretations for Sprouting, Intussusception, Ansiform, and Coalescent Types of Angiogenesis.

机构信息

Department of Pathological Anatomy, Yaroslavl State Medical University, Yaroslavl 150000, Russia.

Department of Anatomy and Topographic Anatomy, Ivanovo State Medical University, Ivanovo 153012, Russia.

出版信息

Int J Mol Sci. 2024 Aug 6;25(16):8575. doi: 10.3390/ijms25168575.

DOI:10.3390/ijms25168575

PMID:39201261

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11354496/

Abstract

Angiogenesis, or the development of blood vessels by growing from already-formed vessels, is observed in embryonic development, physiological cyclical processes such as wound healing, the encapsulation of foreign bodies, tumor growth, and some other situations. In this review, we analyze the cellular mechanisms of angiogenesis, namely, angiogenesis by sprouting, ansiform (by loop formation) angiogenesis, coalescent angiogenesis, and angiogenesis by intussusception (splitting the capillary into two channels). The analysis of data revealed a lot of unanswered questions and contradictions. Here, we propose several new models of angiogenesis explaining these contradictions.

摘要

血管生成，即从已形成的血管中生长出新的血管，在胚胎发育、伤口愈合等生理周期性过程、异物包裹、肿瘤生长和其他一些情况下都有观察到。在这篇综述中，我们分析了血管生成的细胞机制，即发芽式血管生成、丝状（通过环形成）血管生成、融合式血管生成和内套叠（将毛细血管分裂成两个通道）式血管生成。对这些数据的分析揭示了许多尚未解决的问题和矛盾。在这里，我们提出了几个新的血管生成模型来解释这些矛盾。