Medical Clinic No. 1, Internal Medicine Department, University of Medicine and Pharmacy "Iuliu Hatieganu", 400006 Cluj-Napoca, Romania.
Interventional Cardiology Department, Cluj County Emergency Hospital, 400006 Cluj-Napoca, Romania.
Int J Mol Sci. 2024 Aug 11;25(16):8749. doi: 10.3390/ijms25168749.
Multiple clinical trials have reported favorable outcomes after drug-coated balloon therapy for peripheral artery disease in above-the-knee and below-the-knee lesions and in both de novo and in-stent restenosis. However, there are still insufficient data to identify and tackle the risk factors associated with a higher risk of restenosis, which is the primary concern for patients who are treated with an endovascular approach. A modern armamentarium, which includes improved lesion preparation techniques such as plaque modification balloons, mechanical atherectomy, intravascular lithotripsy, and imaging, is crucial for obtaining better long-term clinical outcomes. Moreover, a better understanding of the molecular properties of drug-coated balloons has led to improved devices that could tackle the shortcomings of previous generations. This comprehensive review focuses on drug-coated balloon technology as a tool to treat peripheral artery disease and the effects of the molecular mechanisms involved in preventing vascular restenosis.
多项临床试验报告了药物涂层球囊治疗膝上和膝下病变、新发和支架内再狭窄的外周动脉疾病的良好结果。然而，仍然缺乏足够的数据来识别和解决与再狭窄风险增加相关的风险因素，这是接受血管内治疗的患者主要关注的问题。一个现代的治疗手段，包括改进的病变准备技术，如斑块修饰球囊、机械旋切术、血管内碎石术和影像学，对于获得更好的长期临床结果至关重要。此外，对药物涂层球囊的分子特性有了更好的理解，导致了改进的设备，可以解决前几代设备的缺点。本综述重点介绍了药物涂层球囊技术作为治疗外周动脉疾病的工具，以及涉及预防血管再狭窄的分子机制的影响。
