Insights into E-Cadherin Impairment in -Unaltered Invasive Lobular Carcinoma: A Comprehensive Bioinformatic Study.

Invasive lobular carcinoma exhibits unique morphological features frequently associated with alterations in . Although some studies have identified abnormalities in adhesion factors other than E-cadherin, the molecular mechanisms underlying E-cadherin abnormalities in -unaltered invasive lobular carcinoma remain poorly understood. In this study, we investigated the molecular underpinnings of E-cadherin dysregulation in invasive lobular carcinoma in the absence of gene alterations, using comprehensive bioinformatic analyses. We conducted a comparative study of -mutated and non-mutated invasive lobular carcinoma and evaluated the differences in mRNA levels, reverse-phase protein array, methylation, and miRNAs. We observed that invasive lobular carcinoma cases without alterations exhibited a significantly higher incidence of the Claudin-low subtype ( < 0.01). The results of the reverse-phase protein array indicate no significant difference in E-cadherin expression between -mutated and non-mutated cases. Therefore, abnormalities in E-cadherin production also exist in non-mutated invasive lobular carcinoma. Considering that there are no differences in mRNA levels and methylation status, post-translational modifications are the most plausible explanation for the same. Hence, future studies should focus on elucidating the mechanism underlying E-cadherin inactivation via post-translational modifications in non-mutated invasive lobular carcinoma.