Tsuruoka T, Yamada Y, Goi H, Miyauchi K, Miyata A, Inouye S, Ishino F, Hirata A, Matsuhashi M
J Antimicrob Chemother. 1985 Feb;15(2):159-71. doi: 10.1093/jac/15.2.159.
MT-141, a new cephamycin (7 alpha-methoxy-cephalosporin) antibiotic with a D-cysteine moiety in its 7 beta-side chain, has binding affinities to penicillin-binding proteins of Escherichia coli and an inhibitory action on their transpeptidase activity similar to those of other structurally related cephamycins. Yet this antibiotic was found to exert an exceedingly strong and rapid lytic action on sensitive Gram-negative bacteria such as E. coli, Klebsiella pneumoniae, Serratia marcescens and Salmonella enteritidis. Not only rapidly growing cells, but also slowly growing dense cells of the above bacteria could be lysed by this antibiotic at low concentrations. In the presence of 20% sucrose, low concentrations of MT-141 induced smooth-surfaced single and twin bulges of the putative growth zone of the cells and irregularly orientated rough-surfaced bulges. Probably the 7 beta-side chain structure of this antibiotic is involved in its rapid and strong bacteriolytic action.
MT - 141是一种新型头孢霉素（7α - 甲氧基 - 头孢菌素）抗生素，其7β侧链含有D - 半胱氨酸部分，对大肠杆菌的青霉素结合蛋白具有结合亲和力，并且对其转肽酶活性具有抑制作用，这与其他结构相关的头孢霉素类似。然而，发现这种抗生素对敏感的革兰氏阴性菌，如大肠杆菌、肺炎克雷伯菌、粘质沙雷氏菌和肠炎沙门氏菌具有极其强烈且迅速的溶菌作用。不仅快速生长的细胞，而且上述细菌的缓慢生长的致密细胞在低浓度下也可被这种抗生素裂解。在20%蔗糖存在的情况下，低浓度的MT - 141会诱导细胞假定生长区出现表面光滑的单个和成对凸起以及不规则取向的表面粗糙的凸起。这种抗生素的7β侧链结构可能与其快速且强烈的溶菌作用有关。
