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接种量对头孢米诺及其他四种β-内酰胺类抗生素对大肠杆菌溶菌活性的影响。

Effect of inoculum size on bacteriolytic activity of cefminox and four other beta-lactam antibiotics against Escherichia coli.

作者信息

Soriano F, Edwards R, Greenwood D

机构信息

Department of Microbiology, University Hospital, Queen's Medical Centre, Nottingham, United Kingdom.

出版信息

Antimicrob Agents Chemother. 1992 Jan;36(1):223-6. doi: 10.1128/AAC.36.1.223.

DOI:10.1128/AAC.36.1.223
PMID:1590693
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC189272/
Abstract

MICs and turbidimetric experiments revealed a negligible inoculum effect with two Escherichia coli strains exposed to cefminox and cefoxitin, whereas a marked inoculum effect was revealed after exposure to cefotaxime, ceftizoxime, and imipenem. The activities of the cephamycins were associated with spheroplast formation and bacteriolysis at concentrations close to the MIC, whereas the other agents induced the formation of filaments or, in the case of imipenem, rounded cells.

摘要

最低抑菌浓度（MIC）和比浊法实验显示，两种大肠杆菌菌株暴露于头孢米诺和头孢西丁时接种量效应可忽略不计，而暴露于头孢噻肟、头孢唑肟和亚胺培南后则显示出明显的接种量效应。头孢霉素类药物的活性与接近最低抑菌浓度时原生质球的形成和细菌溶解有关，而其他药物则诱导丝状形成，或就亚胺培南而言，诱导圆形细胞形成。

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本文引用的文献

1
The inhibitory quotient. A method for interpreting minimum inhibitory concentration data.抑制商数。一种解释最低抑菌浓度数据的方法。
JAMA. 1981 Oct 2;246(14):1575-8. doi: 10.1001/jama.246.14.1575.
2
Differences between ceftizoxime and its stereoisomer in antibacterial activity and affinity for penicillin-binding proteins.头孢唑肟与其立体异构体在抗菌活性及对青霉素结合蛋白的亲和力方面的差异。
Antimicrob Agents Chemother. 1981 Mar;19(3):393-6. doi: 10.1128/AAC.19.3.393.
3
In vitro and in vivo antibacterial activities of MT-141, a new semisynthetic cephamycin, compared with those of five cephalosporins.新型半合成头孢霉素MT-141与五种头孢菌素的体外及体内抗菌活性比较
Antimicrob Agents Chemother. 1984 Nov;26(5):722-9. doi: 10.1128/AAC.26.5.722.
4
Antibacterial activity of cefotaxime.头孢噻肟的抗菌活性。
J Antimicrob Chemother. 1980 Sep;6 Suppl A:37-46. doi: 10.1093/jac/6.suppl_a.37.
5
Observations on the mode of action of cefoxitin.头孢西丁作用方式的观察
Ann N Y Acad Sci. 1974 May 10;235(0):406-25. doi: 10.1111/j.1749-6632.1974.tb43280.x.
6
Comparison of the responses of Escherichia coli and proteus mirabilis to seven beta-lactam antibodies.大肠杆菌和奇异变形杆菌对七种β-内酰胺抗体反应的比较。
J Infect Dis. 1973 Aug;128(2):211-22. doi: 10.1093/infdis/128.2.211.
7
The bacteriolytic action of MT-141, a new cephamycin antibiotic, on gram-negative bacteria.新型头孢霉素抗生素MT-141对革兰氏阴性菌的溶菌作用。
J Antimicrob Chemother. 1985 Feb;15(2):159-71. doi: 10.1093/jac/15.2.159.
8
Antibacterial activity of cefminox against anaerobes.头孢米诺对厌氧菌的抗菌活性。
J Antibiot (Tokyo). 1985 May;38(5):649-60. doi: 10.7164/antibiotics.38.649.
9
In vivo significance of the inoculum effect of antibiotics on Escherichia coli.抗生素对大肠杆菌接种量效应的体内意义
Eur J Clin Microbiol Infect Dis. 1988 Jun;7(3):410-2. doi: 10.1007/BF01962350.
10
Pharmacokinetics of cephem antibiotics in exudate of pelvic retroperitoneal space after radical hysterectomy and pelvic lymphadenectomy.根治性子宫切除术和盆腔淋巴结清扫术后盆腔腹膜后间隙渗出液中头孢菌素类抗生素的药代动力学
Antimicrob Agents Chemother. 1990 Jun;34(6):1160-4. doi: 10.1128/AAC.34.6.1160.