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miRNAs 在疼痛管理中的治疗意义：综述。

Therapeutic Implication of miRNAs as an Active Regulatory Player in the Management of Pain: A Review.

机构信息

The Steve and Cindy Rasmussen Institute for Genomic Medicine at Nationwide Children's Hospital, Columbus, OH 43205, USA.

Department of Pharmacology, College of Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea.

出版信息

Genes (Basel). 2024 Jul 31;15(8):1003. doi: 10.3390/genes15081003.

DOI:10.3390/genes15081003
PMID:39202362
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11353898/
Abstract

Chronic pain is frequently associated with neuropathy, inflammation, or the malfunctioning of nerves. Chronic pain is associated with a significant burden of morbidity due to opioid use, associated with addiction and tolerance, and disability. MicroRNAs (miRs) are emerging therapeutic targets to treat chronic pain through the regulation of genes associated with inflammation, neuronal excitability, survival, or de-differentiation. In this review, we discuss the possible involvement of miRs in pain-related molecular pathways. miRs are known to regulate high-conviction pain genes, supporting their potential as therapeutic targets.

摘要

慢性疼痛常与神经病变、炎症或神经功能障碍有关。由于阿片类药物的使用，与成瘾和耐受以及残疾相关，慢性疼痛与发病率的显著负担有关。microRNAs（miRs）是通过调节与炎症、神经元兴奋性、存活或去分化相关的基因来治疗慢性疼痛的新兴治疗靶点。在这篇综述中，我们讨论了miRs 参与疼痛相关分子途径的可能性。miRs 已知可调节高置信度疼痛基因，支持它们作为治疗靶点的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70f3/11353898/46a655d12699/genes-15-01003-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70f3/11353898/0a4a4ca28784/genes-15-01003-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70f3/11353898/8fd942ca7f63/genes-15-01003-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70f3/11353898/46a655d12699/genes-15-01003-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70f3/11353898/0a4a4ca28784/genes-15-01003-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70f3/11353898/8fd942ca7f63/genes-15-01003-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70f3/11353898/46a655d12699/genes-15-01003-g003.jpg

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Nat Cell Biol. 2023 Feb;25(2):309-322. doi: 10.1038/s41556-022-01055-y. Epub 2023 Jan 16.
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Association between inflammation, reward processing, and ibuprofen-induced increases of miR-23b in astrocyte-enriched extracellular vesicles: A randomized, placebo-controlled, double-blind, exploratory trial in healthy individuals.
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Brain Behav Immun Health. 2022 Dec 24;27:100582. doi: 10.1016/j.bbih.2022.100582. eCollection 2023 Feb.
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Int J Mol Med. 2023 Jan;51(1). doi: 10.3892/ijmm.2022.5210. Epub 2022 Dec 9.
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