Hu Cheng, He Menglin, Xu Qian, Tian Weiqian
Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, China.
Front Neurosci. 2021 Dec 23;15:760936. doi: 10.3389/fnins.2021.760936. eCollection 2021.
Neuropathic pain (NP) is one of the most common types of clinical pain. The common causes of this syndrome include injury to the central or peripheral nervous systems and pathological changes. NP is characterized by spontaneous pain, hyperalgesia, abnormal pain, and paresthesia. Because of its diverse etiology, the pathogenesis of NP has not been fully elucidated and has become one of the most challenging problems in clinical medicine. This kind of pain is extremely resistant to conventional treatment and is accompanied by serious complications. Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), contribute to diverse biological processes by regulating the expression of various mRNAs involved in pain-related pathways, at the posttranscriptional level. Abnormal regulation of ncRNAs is closely related to the occurrence and development of NP. In this review, we summarize the current state of understanding of the roles of different ncRNAs in the development of NP. Understanding these mechanisms can help develop novel therapeutic strategies to prevent or treat chronic pain.
神经病理性疼痛（NP）是临床疼痛中最常见的类型之一。该综合征的常见病因包括中枢或外周神经系统损伤以及病理变化。NP的特征是自发性疼痛、痛觉过敏、异常疼痛和感觉异常。由于其病因多样，NP的发病机制尚未完全阐明，已成为临床医学中最具挑战性的问题之一。这种疼痛对传统治疗极具抗性，并伴有严重并发症。非编码RNA（ncRNAs），如微小RNA（miRNAs）、长链非编码RNA（lncRNAs）和环状RNA（circRNAs），通过在转录后水平调节参与疼痛相关途径的各种mRNA的表达，参与多种生物学过程。ncRNAs的异常调节与NP的发生和发展密切相关。在本综述中，我们总结了目前对不同ncRNAs在NP发生发展中作用的理解现状。了解这些机制有助于开发预防或治疗慢性疼痛的新治疗策略。
