Department of Radiation Oncology, NYC Health + Hospitals/Elmhurst, Queens, NY 11373, USA.
The Mount Sinai Hospital, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Genes (Basel). 2024 Aug 7;15(8):1039. doi: 10.3390/genes15081039.
The subterranean blind mole rat, , has evolved significantly over 47 million years to thrive in its underground habitat. A key enzyme in this adaptation is heparanase, which degrades heparan sulfate (HS) in the extracellular matrix (ECM), facilitating angiogenesis and releasing growth factors for endothelial cells. heparanase has various splice variants influencing tumor growth and metastasis differently. We report a novel splice variant from a hypoxia-exposed kidney sample resulting from exon 12 skipping. This variant maintains the translation frame but lacks enzymatic activity, offering insights into 's unique adaptations.
地下盲鼹鼠 经过 4700 多万年的进化，已显著适应其地下栖息地。这种适应的一个关键酶是肝素酶，它可降解细胞外基质 (ECM) 中的硫酸乙酰肝素 (HS)，促进血管生成并释放内皮细胞的生长因子。肝素酶有多种剪接变体，它们对肿瘤生长和转移的影响不同。我们报告了一种来自缺氧暴露肾脏样本的新型剪接变体，该变体通过外显子 12 跳跃而缺失。该变体保持翻译框架但缺乏酶活性，为 的独特适应提供了新的见解。
