Transplant-Nephrology Department, University Hospital Martin, Kollárova 2, 036 01 Martin, Slovakia.
Department of I. Internal Medicine, University Hospital Martin, Jessenius Faculty of Medicine of Comenius University, 03601 Martin, Slovakia.
Medicina (Kaunas). 2024 Jul 26;60(8):1210. doi: 10.3390/medicina60081210.
: Post-transplant diabetes mellitus (PTDM) is a significant risk factor for the survival of graft recipients and occurs in 10-30% of patients after kidney transplant (KT). PTDM is associated with premature cardiovascular morbidity and mortality. Weight gain, obesity, and dyslipidemia are strong predictors of PTDM, and by modifying them with an active lifestyle it is possible to reduce the incidence of PTDM and affect the long-term survival of patients and grafts. The aim of our study was to determine the effect of regular physical activity on the development of PTDM and its risk factors in patients after KT. : Participants in the study had to achieve at least 150 min of moderate-intensity physical exertion per week. The study group ( = 22) performed aerobic or combined (aerobic + strength) types of sports activities. Monitoring was provided by the sports tracker (Xiaomi Mi Band 4 compatible with the Mi Fit mobile application). The control group consisted of 22 stable patients after KT. Each patient underwent an oral glucose tolerance test (oGTT) at the end of the follow-up. The patients in both groups have the same immunosuppressive protocol. The total duration of the study was 6 months. : The patients in the study group had significantly more normal oGTT results at 6 months compared to the control group ( < 0.0001). In the control group, there were significantly more patients diagnosed with PTDM ( = 0.0212) and with pre-diabetic conditions (impaired plasma glucose and impaired glucose tolerance) at 6 months ( = 0.0078). : Regular physical activity after KT provides significant prevention against the development of pre-diabetic conditions and PTDM.
: 移植后糖尿病（PTDM）是移植物受者存活的重要危险因素，在肾移植（KT）后 10-30%的患者中发生。PTDM 与心血管疾病发病早和死亡率高有关。体重增加、肥胖和血脂异常是 PTDM 的强烈预测因素，通过积极的生活方式来改变这些因素，有可能降低 PTDM 的发生率，并影响患者和移植物的长期存活。我们的研究目的是确定规律的体育活动对 KT 后患者 PTDM 及其危险因素的发展的影响。 : 研究参与者每周必须至少进行 150 分钟的中等强度体育锻炼。研究组（n=22）进行有氧运动或组合（有氧运动+力量）类型的体育活动。监测由运动追踪器（与小米米乐队 4 兼容的小米健身应用程序）提供。对照组由 22 名 KT 后稳定的患者组成。每位患者在随访结束时都进行口服葡萄糖耐量试验（oGTT）。两组患者都有相同的免疫抑制方案。研究总持续时间为 6 个月。 : 与对照组相比，研究组患者在 6 个月时 oGTT 结果正常的明显更多（<0.0001）。在对照组中，在 6 个月时，有更多的患者被诊断为 PTDM（=0.0212）和处于糖尿病前期状态（血糖受损和糖耐量受损）（=0.0078）。 : KT 后规律的体育活动对预防糖尿病前期状态和 PTDM 有显著作用。
