Department of Laboratory Medicine, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, 807 Hogukro Buk-gu, Daegu 41404, Republic of Korea.
QBM Research Institute, QBM Co., Ltd., 7-25 Gangnam-daero 27-gil, Seocho-gu, Seoul 06752, Republic of Korea.
Medicina (Kaunas). 2024 Aug 5;60(8):1265. doi: 10.3390/medicina60081265.
: Deep seawater has been shown to restore pancreatic function in obese diabetic mice and considerably improve the homeostatic model assessment for insulin resistance, total cholesterol, and low-density lipoprotein cholesterol concentrations in patients with impaired fasting glucose or glucose tolerance. In this study, the effect of 12-week daily consumption of magnesium (Mg)-containing deep seawater mineral extracts on blood glucose concentration and insulin metabolism-associated indicators was investigated in patients with impaired glucose tolerance. : In this 12-week randomized, double-blind trial, patients ( = 37) with impaired glucose tolerance consumed deep seawater mineral extracts. Changes in blood glucose concentration and related indicators were compared between the treatment group and placebo group ( = 38). : The fasting insulin, C-peptide, homeostatic model assessment for insulin resistance, quantitative insulin sensitivity check index, homeostatic model assessment of beta-cell function, and Stumvoll insulin sensitivity index values in the deep seawater mineral extract group showed improvements compared with the placebo group. However, no significant differences between groups were observed in fasting blood glucose, postprandial blood glucose, glycated hemoglobin, or incremental area under the curve values. : Oral supplementation with deep seawater mineral extracts enriched in Mg markedly improves insulin sensitivity in patients with pre-diabetes. This study illustrates the potential clinical application of natural Mg from deep seawater to alleviate insulin resistance in patients with pre-diabetes. : This trial was retrospectively registered with Clinical Research information Service (CRIS), No. KCT0008695, on 8 August 2023.
: 深海水中含有镁，已被证明可恢复肥胖型糖尿病小鼠的胰腺功能，并显著改善空腹血糖受损或葡萄糖耐量受损患者的胰岛素抵抗稳态模型评估、总胆固醇和低密度脂蛋白胆固醇浓度。在这项研究中，研究人员观察了富含镁的深海水矿物质提取物在 12 周的日常摄入对葡萄糖耐量受损患者血糖浓度和胰岛素代谢相关指标的影响。: 在这项为期 12 周的随机、双盲试验中，葡萄糖耐量受损的患者（n = 37）饮用了深海水矿物质提取物。比较了治疗组和安慰剂组（n = 38）的血糖浓度变化和相关指标。: 与安慰剂组相比，深海水矿物质提取物组的空腹胰岛素、C 肽、胰岛素抵抗稳态模型评估、定量胰岛素敏感性检查指数、胰岛素β细胞功能稳态模型评估和 Stumvoll 胰岛素敏感性指数值有所改善。然而，两组间的空腹血糖、餐后血糖、糖化血红蛋白或增量曲线下面积值均无显著差异。: 口服富含镁的深海水矿物质提取物可显著改善糖尿病前期患者的胰岛素敏感性。本研究说明了天然深海水中镁的潜在临床应用，可缓解糖尿病前期患者的胰岛素抵抗。: 本试验于 2023 年 8 月 8 日在临床研究信息服务（CRIS）上进行了回顾性注册，编号为 KCT0008695。
