Department of Laboratory Medicine, Kyungpook National University Hospital, 130 Dongdukro Jung-gu, Daegu 41944, Korea.
Bio-Medical Research Institute, Kyungpook National University Hospital, 135 Dongdukro Jung-gu, Daegu 41940, Korea.
Nutrients. 2020 Feb 18;12(2):515. doi: 10.3390/nu12020515.
Previous in vitro and in vivo studies have shown that the antidiabetic effect of balanced deep-sea water (BDSW) works through the suppression of hyperglycemia and improvement of glucose tolerance. Based on these promising results, we conducted an eight week randomized, double-blinded crossover trial of the effects of BDSW in prediabetic adults. The subjects consumed 440 mL of BDSW (hardness 4000) per day, and maintained an otherwise normal lifestyle and diet throughout. Efficacy assessments were made by measuring fasting glucose, postprandial glucose, fasting insulin, homeostasis model assessment for insulin resistance (HOMA-IR), C-peptide, glycosylated hemoglobin, lipid metabolism indicators, and physical metrics, along with safety assessments. Fasting insulin and HOMA-IR values of the BDSW group were significantly lower than those of the placebo group after eight weeks of BDSW ingestion. Total cholesterol and low-density lipoprotein-cholesterol were also significantly decreased in the BDSW group after eight weeks of BDSW ingestion compared with the placebo group. There were no statistically and clinically meaningful changes in adverse events, physical examination, laboratory medicine examination, or vital signs of the BDSW intake group. These results suggested that the intake of BDSW in prediabetic adults can improve glucose metabolism and lipid profiles and is safe for human consumption.
先前的体外和体内研究表明，平衡深海水（BDSW）的降血糖作用是通过抑制高血糖和改善葡萄糖耐量来实现的。基于这些有希望的结果，我们对 BDSW 对糖尿病前期成年人的影响进行了为期八周的随机、双盲交叉试验。受试者每天饮用 440 毫升 BDSW（硬度为 4000），并在整个试验期间保持正常的生活方式和饮食。通过测量空腹血糖、餐后血糖、空腹胰岛素、胰岛素抵抗评估的稳态模型（HOMA-IR）、C 肽、糖化血红蛋白、脂代谢指标和身体指标来评估疗效，并进行安全性评估。在饮用 BDSW 八周后，BDSW 组的空腹胰岛素和 HOMA-IR 值明显低于安慰剂组。与安慰剂组相比，在饮用 BDSW 八周后，BDSW 组的总胆固醇和低密度脂蛋白胆固醇也明显降低。BDSW 摄入组的不良事件、体检、实验室医学检查或生命体征均无统计学意义和临床意义的变化。这些结果表明，糖尿病前期成年人摄入 BDSW 可以改善葡萄糖代谢和血脂谱，并且对人体安全。
